Associacion Of 308G>A And -238G>A TNF-α Polymorphisms With Asthma In A Spanish Population

  1. Batista, J.C. 1
  2. Padrón, J.R. 1
  3. Isidoro-García, M. 1
  4. Sanz, C.S. 1
  5. García, V. 1
  6. Benito, D. 1
  7. Hernández, L. 1
  8. Dávila, I.J. 1
  9. Lorente, F. 1
  1. 1 Hospital Universitario de Salamanca

    Hospital Universitario de Salamanca

    Salamanca, España


Journal of Allergy and Clinical Immunology

ISSN: 0091-6749

Year of publication: 2010

Volume: 125

Issue: 2

Pages: AB50

Type: Article

DOI: 10.1016/J.JACI.2009.12.229 GOOGLE SCHOLAR

More publications in: Journal of Allergy and Clinical Immunology


Cited by

  • Web of Science Cited by: 0 (26-09-2023)
  • Dimensions Cited by: 0 (25-03-2023)

JCR (Journal Impact Factor)

  • Year 2010
  • Journal Impact Factor: 9.273
  • Journal Impact Factor without self cites: 7.427
  • Article influence score: 2.355
  • Best Quartile: Q1
  • Area: ALLERGY Quartile: Q1 Rank in area: 1/22 (Ranking edition: SCIE)
  • Area: IMMUNOLOGY Quartile: Q1 Rank in area: 9/134 (Ranking edition: SCIE)

SCImago Journal Rank

  • Year 2010
  • SJR Journal Impact: 4.061
  • Best Quartile: Q1
  • Area: Immunology Quartile: Q1 Rank in area: 15/203
  • Area: Immunology and Allergy Quartile: Q1 Rank in area: 13/185


(Data updated as of 25-03-2023)
  • Total citations: 0
  • Recent citations: 0
  • Field Citation Ratio (FCR): 0.0


RATIONALE: Tumor necrosis factor (TNFα) is a pro-inflammatory cytokine that plays an important role in the pathogenesis of asthma. TNFα gene promoter polymorphisms -308G>A and -238G>A seem to be involved in the production of protein at the transcriptional level. We have examined the association of both polymorphisms with the presence of asthma in a Spanish population. METHODS: We analyzed 216 patients diagnosed of asthma according to GINA guidelines and 157 non-asthmatic, non-atopic controls. DNA was extracted from peripheral blood using an inmunomagnetic procedure. Genotyping was performed using site-specific PCR method. The SPSS software, version 17.0 and the Shesis software platform were employed for statistical analyses. RESULTS: We found an association between the presence of asthma and the polymorphism -308G>A of TNFα. The A allele was more frequent in the group of patients (Fisher's p value of 0.016). The SNP 238G>A did not show a significant association. However, the haplotype analysis showed an association with asthma phenotype. The AG (-308G>A and -238G>A) combination was more common in asthma (Fisher's p value of 0.017 O.R. [95%CI] = 1.911 [1.113-3.282]) but no association was observed for the AA haplotype. The Hardy-Weinberg Equilibrium was observed in all cases. CONCLUSIONS: The polymorphism -308G>A of TNFα is related to the asthma phenotype in our population. This association could be due to a modification in the expression of TNFα. This association could be modified by the combination with alleles of other SNPs. Haplotype analysis provide a more complete information regarding genetic association.