Heart valve tissue engineering: how far is the bedside from the bench?

  1. Sanz-Garcia, A. 25
  2. Oliver-de-la-Cruz, J. 6
  3. Mirabet, V. 1
  4. Gandía, C. 2
  5. Villagrasa, Alejandro. 2
  6. Sodupe, E. 3
  7. Escobedo-Lucea, C. 25
  1. 1 Cell and Tissue Bank, Regional Transfusion Center, Valencia, Spain
  2. 2 University of Helsinki
    info

    University of Helsinki

    Helsinki, Finlandia

    ROR https://ror.org/040af2s02

  3. 3 Universidad de La Rioja
    info

    Universidad de La Rioja

    Logroño, España

    ROR https://ror.org/0553yr311

  4. 4 Fundación Jiménez Díaz
    info

    Fundación Jiménez Díaz

    Madrid, España

    ROR https://ror.org/049nvyb15

  5. 5 Tokyo Women's Medical University
    info

    Tokyo Women's Medical University

    Tokio, Japón

    ROR https://ror.org/03kjjhe36

  6. 6 St. Anne’s University Hospital Brno
    info

    St. Anne’s University Hospital Brno

    Brno, República Checa

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Revista:
Expert Reviews in Molecular Medicine

ISSN: 1462-3994

Año de publicación: 2015

Volumen: 17

Páginas: e16

Tipo: Artículo

DOI: 10.1017/ERM.2015.15 PMID: 26399177 SCOPUS: 2-s2.0-84961040885 WoS: WOS:000364929100001 GOOGLE SCHOLAR

Otras publicaciones en: Expert Reviews in Molecular Medicine

Resumen

Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Our review focuses on the current status of heart valve (HV) therapy and the challenges that must be solved in the development of new approaches based on tissue engineering. Scientists and physicians have proposed tissue-engineered heart valves (TEHVs) as the most promising solution for HV replacement, especially given that they can help to avoid thrombosis, structural deterioration and xenoinfections. Lastly, TEHVs might also serve as a model for studying human valve development and pathologies.