Implicaciones de la tirosina cinasa p125FAK en procesos de secreción pancreática

  1. Rosado, Juan A.
Supervised by:
  1. Ginés María Salido Ruiz Director
  2. Luis Jesús García Marín Director

Defence university: Universidad de Extremadura

Fecha de defensa: 22 December 1997

Committee:
  1. José Miguel López Novoa Chair
  2. María José Pozo Andrada Secretary
  3. Guillermo Álvarez de Toledo Naranjo Committee member
  4. Antonio Farré Viladrich Committee member
  5. José Julián Calvo Andrés Committee member

Type: Thesis

Teseo: 63663 DIALNET lock_openDialnet editor

Abstract

Stimulation of pancreatic acinar cells with CCK-8 or the cholinergic agonist, carbachol, induces tyrosine phosphorylation of the tyrosine kinase p125FAK and its substrate, paxillin. This event, which involves the activation of phospholipase C and the integrity of the actin cytoskeleton, is not essential for the secretory process of pancreatic acinar cells.