Influencia de la diabetes mellitus en la patogenia de la anemia en la insuficiencia renal estadios III a V antes de iniciar tratamiento renal sustitutivo

Abstract

Although anemia is a frequent complication of chronic kidney disease (CKD), there are few reports on the prevalence of this problem in Spain in CKD non-dialysis patients. On the other hand, it has been suggested that diabetes mellitus and insulin resistance could affect iron metabolism. Our aim is to evaluate a group of patients (with/without CKD; with/without diabetes mellitus) classified by the serum cystatin C levels. In every case will be quantified creatinine, cystatin C, Fe, transferrin, and transferrin saturation index, as well as 24h microalbuminuria. Glomerular filtration rate will be estimated by the MDRD-4 and Hoek equations. It shall considered as normal a transferrin saturation index > 30%. Ferritin shall be considered as low below 30 ng/ml and high above 100 ng/ml. The diagnosis of iron depots blockade will be made on the presence of low transferrin saturation index and high ferritin together.