Modulación por las isoformas de Ras de la síntesis de matriz extracelular y proliferación en fibroblastos
- José Miguel López Novoa Director
- José Carlos Martínez Salgado Director
Defence university: Universidad de Salamanca
Fecha de defensa: 01 June 2009
- María Jesús Monte Río Chair
- María Nélida Eleno Balboa Secretary
- María Piedad Ruiz Torres Committee member
- José Manuel Valdivieso Revilla Committee member
- Octavio Alda Torrubia Committee member
Type: Thesis
Abstract
Fibroblasts are the main ECM-producing cells (extracellular matrix), but depending on the type of tissue cell types can appear other residents. The fibroblasts produce large amounts of ECM, inducing the replacement of the usual components of tissue by fibrous material. Knowledge of the molecular mechanisms governing the deposition and degradation of ECM in physiological and pathophysiological conditions may be useful in designing preventive strategies, thereby reducing the progression of these pathological processes that occur with fibrosis