Síntesis de piridín alcaloides inhibidores de fosfolipasa A2espongidinas

Abstract

This work is part of the field of Natural Products. To this end, we have set the following objectives: - Transformation of sclareol in methyl isoanticopalato and then a tricyclic advanced intermediate possessing rings A, B and C of the target molecules with stereocenters controlled from the starting material. - Development of a synthetic route from this tricyclic intermediate access to the ring D, which contains the group nitrogen molecules present in espongidinas. This strategy will lead to immediate objective synthesis decarboxiespongolactamas. Implementation of the strategy-tuning in the synthesis of decarboxiespongolactamas espongidinas the synthesis of A and D.