Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer

  1. García-Cremades Mira, María
Supervised by:
  1. Iñaki F. Trocóniz Director

Defence university: Universidad de Navarra

Fecha de defensa: 29 September 2017

Committee:
  1. José Martínez Lanao Chair
  2. Maria Jesus Garrido Cid Secretary
  3. Sonya Catherine Tate Committee member
  4. Victor Mangas Sanjuan Committee member
  5. Julen Oyarzabal Santamarina Committee member

Type: Thesis

Teseo: 141692 DIALNET lock_openDadun editor

Abstract

This thesis performs a retrospective evaluation of data generated for the cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug development. Using these data, and through data analysis and simulations-based translational exercise, a model-based framework in oncology, relating in vitro and in vivo pre-clinical pharmacokinetic (PK) and tumour size (TS) information, with response outcome obtained in clinical trials, has been developed.