Evaluación de nuevos donadores de óxido nítrico en el trasplante renal experimental

  1. María Begoña García Cenador
  2. María Teresa Grande Rodríguez
  3. Penélope Diana Sánchez González
  4. Pablo Rodríguez Barc
  5. Joaquín F. López Marcos
  6. Francisco Javier García Criado
  7. Marisabel Mourelle
  8. José Miguel López Novoa
Journal:
Diálisis y trasplante: publicación oficial de la Sociedad Española de Diálisis y Trasplante

ISSN: 1886-2845

Year of publication: 2010

Volume: 31

Issue: 2

Pages: 30-36

Type: Article

DOI: 10.1016/J.DIALIS.2010.01.001 DIALNET GOOGLE SCHOLAR

More publications in: Diálisis y trasplante: publicación oficial de la Sociedad Española de Diálisis y Trasplante

Metrics

Cited by

  • Scopus Cited by: 0 (30-01-2024)
  • Dimensions Cited by: 0 (22-12-2023)

SCImago Journal Rank

  • Year 2010
  • SJR Journal Impact: 0.166
  • Best Quartile: Q3
  • Area: Urology Quartile: Q3 Rank in area: 55/95
  • Area: Transplantation Quartile: Q4 Rank in area: 30/39

Dimensions

(Data updated as of 22-12-2023)
  • Total citations: 0
  • Recent citations (2 years): 0

Abstract

Introduction and objectives: Given the importance of minimizing renal damage due to ischemia/reperfusion in organ transplants, we evaluated prophylactic treatments to control inflammatory response, using distinct nitric oxide donors. Methods: We used experimental models of ischemia/reperfusion and kidney transplants using LA-803, LA-807, LA-810 donors and molsidomine. Renal function, neutrophil infiltration, oxidative stress, pro- and anti-inflammatory cytokines, nitric oxide, leukocyte-endothelium interaction and nuclear transcription were studied. Results: LA-803 demonstrated the greatest effectiveness in controlling inflammatory response and was selected to continue the study. We found a decrease in inflammatory response, oxidative stress and neutrophil infiltration and lesser endothelial damage with preservation of organ function. Conclusions: We believe that the use of specific nitric oxide donors could be highly useful in organ transplantation, increasing cellular viability and organ function post-transplantation.