Microencapsulación de ciprofloxacino en microesferas de albumina y liposomas (Albusomas)

  1. DUQUE AGUILAR, Juan José
  2. JESÚS DEL VALLE, María José 1
  3. SÁNCHEZ NAVARRO, Amparo 1
  1. 1 Departamento de Ciencias Farmacéuticas (Farmacia y Tecnología Farmacéutica). Facultad de Farmacia, Universidad de Salamanca
Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2017

Volume: 2

Issue: 2

Pages: 51-58

Type: Article

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Abstract

: Fluoroquinolones are bactericidal agents showing a broad antimicrobial spectrum used for several infectious diseases. Liposomes are excellent carriers for controlled drug delivery and albumin shows a great capacity for binding and transport of solutes. The aim of this study was to incorporate ciprofloxacin into a formulation based on the combination of liposomes and albumin in order to gather the advantages of both components into a single pharmaceutical vehicle.Liposomes were prepared by sonication, in absence of organic solvents, by using ciprofloxacin solutions of different concentration. The albusomes were prepared by mixing these with bovine serum albumin. The influence of three variables on the drug encapsulation efficiency was evaluated: liposomes composition, ciprofloxacin concentration and albumin amount; an HPLC technique was used for drug quantification.The results of the study reveal that liposomes composition significantly affects the entrapment efficiency registered while ciprofloxacin concentration does not affect this parameter

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