Estudio del proteoma en malaria

  1. MORÁN, Jesús 1
  2. MORENO-PÉREZ, Darwin A 2
  3. PATARROYO, Manuel A 3
  4. MURO, Antonio 1
  1. 1 Laboratorio de Inmunología Parasitaria y Molecular. Unidad de Investigación acreditada por la Junta de CyL “Enfermedades Infecciosas y Tropicales (e-INTRO)”. Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Facultad de Farmacia, Avda. Ldo. Méndez Nieto s/n 37007 Salamanca, España.
  2. 2 Laboratorio de Inmunología Parasitaria y Molecular. Unidad de Investigación acreditada por la Junta de CyL “Enfermedades Infecciosas y Tropicales (e-INTRO)”. Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Facultad de Farmacia, Avda. Ldo. Méndez Nieto s/n 37007 Salamanca, España. Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No.26-20, Bogotá, Colombia.
  3. 3 Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50 No.26-20, Bogotá, Colombia. Universidad del Rosario, Carrera 63D No.24-31, Bogotá, Colombia
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Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2016

Volume: 1

Issue: 1

Pages: 33-40

Type: Article

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Abstract

Malaria is one of the main infectious diseases in the world, particularly in tropical and subtropical areas. Among the species that can cause this disease, in recent years P. vivax has been growing due to its own attributes, which make it highly difficult to eradicate.This study was focused on analyzing and identifying the proteome of P. vivax during the blood stage through a mass spectrometry analysis (LC-MS-MS).Results allowed us to identify 743 proteins, of which 522 never had been described before. Furthermore, the comparison of the expression of these proteins with P. vivax transcriptional profile allowed us to corroborate the adaptive change in the P. vivax VCG-1 strain transcriptome, previously described.

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