Synthesis of combretastatin analogues with antineoplastic properties

Abstract

This doctoral thesis belongs to the field of medicinal and pharmacological chemistry. Its aim is the synthesis, characterization and biological evaluation of three families of aminocombretastatin derivatives, compound with antimitotic and antiangiogenic properties. The first group contains a carbamate function in its structure. These derivatives have been studied as antimitotic and vascular disrupting agents. The second family has been designed from sorafenib drug, with the aim of studying its antiangiogenic effects. Regarding the third family, these have been designed as multitarget compounds, with both antiangiogenic and immunomodulatory properties. Finally, in vivo studies have been developed with the aim of knowing all the perspectives of a biological evaluation process. In conclusion, several compounds have been obtained from the same general structure, able to interact with different targets involved in cancer disease, thus improving the effect offered by aminocombretastatin.