Protocolo diagnóstico de un paciente con anticuerpos antinucleares positivos
- Gómez Castro, Susana
- Sánchez González, M. Dolores
- Montilla Morales, Carlos
- Hidalgo Calleja, Cristina
- Carranco Medina, Tatiana Elizabeth
- Calero Paniagua, Ismael
- Pino Montes, Javier del
ISSN: 0304-5412
Datum der Publikation: 2013
Titel der Ausgabe: Enfermedades del sistema inmune (VII): amiloidosis, sarcoidosis, otras artritis
Serie: 11
Nummer: 34
Seiten: 2106-2110
Art: Artikel
Andere Publikationen in: Medicine: Programa de Formación Médica Continuada Acreditado
Zusammenfassung
Antinuclear antibodies (ANA) are a diverse group of autoantibodies that bind macromolecular components of the cell nucleus. The presence of ANA in serum indicates the existence of an immunological response but not necessarily a disease. The discovery of positive ANA is common in many autoimmune diseases but also can occurs in healthy individuals (frequency increases with age), in diseases with other origin, with the use of some drugs, in tumours or in some infections. The medical request of ANA will be indicated in conditions where an autoimmune systemic disease is suspected. If we find ANA positive, more antibodies will be ordered according to the medical suspicion. Finally, it is important to remember that some autoimmune systemic diseases course with negative autoantibodies, so, the symptoms and the exclusion of other phenomenon are a key component for the diagnosis.