Intervención farmacéutica en el seguimiento de la terapia antirretroviral

Resumen

The elevated cost of antiretroviral treatment demands close follow-up to achieve the effectiveness and efficacy of the treatments implemented, the role of pharmacists in achieving such goals is crucial in the sense that they are mainly involved in directing antiretroviral treatments aimed at generating maximum benefit with the available resources. The aim of the present study was to achieve an appropriate clinical control of HIV+ patients through the correct use of the antiretroviral drugs prescribed. The study was carried out for external HIV-patients with antiretroviral treatment in a university hospital. One and a half years after implementing a Pharmaceutical Care Program, a total of 853 interviews were obtained from 386 HIV+ patients (79.6% of the total), achieving a 9% increase in optimal adherence. In turn, we observed 1060 adverse drugs events and 513 drug related problems. In consequence, we performed 1401 interventions in 365 patients. The degree of patient acceptance of the program had a mean score of 3.7 (scale 0-4). The number of patients whose antiretroviral plasma concentrations were monitored was 381, with a total of 849 determinations. Only 39% of them were within the therapeutic range established for these drugs. Based on pharmacokinetic information, the clinicians performed a dosage adjustment in 16 patients. The experience gained since the implementation of the HIV+ patient follow-up program has proved to be useful for the optimisation of treatments using antiretroviral drugs.