Marcadores inflamatorios en la enfermedad pulmonar obstructiva crónica

  1. Calero Acuña, Carmen
  2. Álvarez Delgado, Alberto
  3. Rojano, B.
  4. Márquez Martín, Eduardo
  5. Cejudo Ramos, Pilar
  6. Ortega Ruiz, Francisco
  7. López-Campos Bodineau, José Luis
Journal:
Revista española de patología torácica

ISSN: 1889-7347

Year of publication: 2009

Volume: 21

Issue: 2

Pages: 76-81

Type: Article

More publications in: Revista española de patología torácica

Abstract

Introduction: Chronic obstructive lung disease (COPD) provokes extra-thoracic affection, with an important systemic inflammatory process. The objective of this report was to evaluate the protein C reactive (PCR) and the so-called acute phase reactants (APR), less in patients with stable COPD. Methods: Observational, case-control study in which the levels of APR were studied in patients with stable COPD, against healthy smokers. The sample was characterized by testing respiratory function (GOLD), exhaled carbon monoxide, Charlson co-morbidity, degree of dyspnea (MRC), annual number of acute attacks and nutritional evaluation (IMC). Two measurements of APR were carried out during two different visits for each patient, determining PCR, complementary factors, alpha 1-antitrypsin, albumin, prealbumin, haptoglobin, speed of sedimentation and fibrinogen. Results: 69 patients with COPD were included (64 men; 65±8 years) and 35 healthy smokers (22 men; 55±0.3 years). PCR, complementary factors 3 and 5, alpha 1-antitrypsin and fibrinogen, were significantly raised in those with COPD (PCR: 5.7±5.9 vs. 3±3.09; p = 0.002; C3: 149.57±25.68 vs. 134.04±24.96 p = 0.006; C5: 14.20±5.3 vs. 12.66±5.2; p = 0.01; alpha 1-antitrypsin: 152.51 (25.58 vs. 141.22 (25.30; p = 0.02; fibrinogen: 3.8 ± 1.07 vs. 4.2 ± 1.1; p=0.016). There were no differences between the two determinations for APR. Conclusions: The results of our study reflect that there are diverse APR related to the systemic inflammation in COPD, whose role in the pathogenesis of the extra-thoracic affectation and in the prognosis of the disease must be appropriately studied.