Leiomiosarcoma primario nasosinusal con origen en cornete mediocaso clínico y revisión de la literatura

  1. Coscarón Blanco, Enrique
  2. Pardal Refoyo, José Luis
  3. Zamora Martínez, Tomás
Revista:
Revista ORL

ISSN: 2444-7986,  2444-7986

Año de publicación: 2012

Volumen: 3

Páginas: 115-129

Tipo: Artículo

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Otras publicaciones en: Revista ORL

Resumen

Los leiomiosarcomas constituyen una variedad muy poco frecuente de tumores nasales o de senos paranasales y por ello su diagnóstico no se sospecha hasta que se realiza biopsia y se estudia la pieza. Su sintomatología es muy similar a la de otros tumores malignos con asiento en esas regiones. Principalmente consiste en dificultad respiratoria nasal, epistaxis, rinorrea y dolor en grado variable. Su diagnóstico histológico se basa en la demostración de un tumor de células musculares lisas con sus criterios morfológicos e inmunohistoquímicos y en la demostración de malignidad. El tratamiento se fundamenta en cirugía con amplio margen de tejido sano ya que no son sensibles a quimioterapia o radioterapia aunque se utilicen en un intento de aumentar la supervivencia. A pesar de todo su pronóstico es muy malo. Presentamos un caso de un voluminoso y extenso leiomiosarcoma nasosinusal con origen en el cornete medio. Describimos las características morfológicas e inmunohistoquímicas de estos tumores y las opciones de tratamiento y realizamos una revisión de la literatura publicada acerca de estos tumores.

Referencias bibliográficas

  • Cahan WG, Woodward HQ, Higinbothan NL, Stewart SW, Coley BL. Sarcoma arising in irradiated bone: Report of eleven cases. Cancer 1948; 1:3- 29.
  • Demirkan F, Unal S, Ceetoglu S, Cinel L. Radiation-induced leiomyosarcomas as second primary tumors-in the head and neck region: Report of 2 cases. J Oral Maxillofac Surg 2003 ;61:259-63.
  • Enzinger MF. Leiomyosarcoma.In Enzinger MF, Weiss SW eds Soft tissue tumors. St Louis. Mosby,1988, 402-21.
  • Farshid G, Pradhan M, Goldblum J, Weiss SW.,Leiomyosarcoma of somatic soft tissues: a tumor of vascular origin with multivariate analysis of outcome in 42 cases. Am J Surg Pathol. 2002 Jan; 26(1): 14-24.
  • Font RL, Jurco S, Brechner RJ. Postradiation leiomyosarcoma of the orbit complicating bilateral retinoblastoma. Arch Ophtalmol 1983; 101:1557-61.
  • Fu YS, Perzin KH. Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: A clinicopathologic study. IV. Smooth muscle tumors (leiomyoma, leiomyosarcoma). Cancer 1975; 35(5): 1300-8.
  • Fujii H, Barnes L, Johnson JT, Kapadia SB. Post-radiation primary intranodal leiomyosarcoma. J Laryngol Otol 1995.
  • Fusconi M, Magliulo G, Della Rocca C, Marcotullio D, Suriano M, De Vincentiis M. Leiomyosarcoma of the sinonasal tract: A case report and literature review. Am J Otolaryngol Head Neck Surg 2002; 23(2): 108-11.
  • Huang HY, Antonescu CR. Sinonasal smooth muscle cell tumors: A clinicopathologic and immunohistochemical analysis of 12 cases with emphasis on the low-grade end of the spectrum. Arch Pathol Lab Med 2003; 127(3): 297- 304.
  • Izumi K, Maeda T, Cheng J, Saku T. Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 80: 310-9.
  • Jenson HB, Montalvo EA, Mc Clain KL , Ench Y, Heard P, Christy BA, Dewalt-Hagan PJ, Moyer MP. Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma. J Med Virol 1999; 57:36-46.
  • Josephson RL, Blair RL, Bedard YC. Leiomyosarcoma of the nose and paranasal sinuses. Otolaryngol Head Neck Surg1985; 93:270-4.
  • Kim JH, Gutierrez FR, Lee EY, Semenkovic J, Bae KT, Ylagan LR. Primary leiomyosarcoma of the pulmonary artery. A diagnostic dilema. Clin Imagin 2003;27:206-211.
  • Kuruvilla A, Wenig BM, Humphrey DM, Heffner DK. Leiomyosarcoma of the sinonasal tract. A clinicopathologic study of nine cases. Arch Otolaryngol Head Neck Surg 1990; 116(11): 1278-86.
  • Lalwani AK, Kaplan MJ. Paranasal sinus leiomyosarcoma after cyclophosphamide and radiation. Otolaryngol Head Neck Surg 1990;103(6): 1039-42.
  • Leader M, Collins M, Patel J, Henry K. Desmin: Its value as a marker of muscle derived tumors using a conventional antibody. Virchows Arch Pathol Anat 1987;411:345-9.
  • Lee ES, Locker J, Nalesnik M , Reyes J, Jaffe R, Alashari M, Nour B, Tzakis A, Dickman PS. The association of Epstein-Barr virus with smooth muscle tumors occurring after organ transplantation. N Engl J Med 1995; 332: 19-25.
  • Lippert BM, Godbersen GS, Lüttges J, Werner JA. Leiomyosarcoma of the nasal cavity. ORL 1996;58:115-20.
  • Manipoud P, Manipoud JP, Kemeny JL, Lafaye M, Salas J. Léiomyosarcome cervical. A propos d´une observation et revue de la littérature. Ann Oto-Laryng 1993 ; 110(2) :109-13.
  • Mierau GW, Greffe BS, Weeks DA. Primary leiomyosarcoma of brain in an adolescent with common variable immunodeficiency syndrome. Ultraestruct Pathol 1997; 21: 301-305.
  • Mindell RS, Calcaterra TC, Ward PH. Leiomyosarcoma of the head and neck: A review of the literature and report of two cases. Laryngoscope 1975;85:904-10.
  • Montgomery E, Goldblum JR, Fisher C. Leiomyosarcoma of the head and neck: A clinicopathological study. Histopathology 2002;40: 518-25.
  • Mueller BU, Butler KM, Higham MC, Husson RN, Montrella KA, Pizzo PA, Feuersteinm IM, Manhunath K . Smooth muscle tumors in children with human immunodeficiency virus infection. Pediatrics 1992; 90: 460-463.
  • Obashi Y, Nakai Y, Muraoka M, Takano H. Asymptomatic leiomyiosarcoma of maxillary sinus accompanied by primary mucocele. Arch Otorhinolaryngol 1984;240:73-8.
  • Patel SG, See ACH, Williamson PA, Archer DJ, Evans PHR. Radiation induced sarcoma of the head and neck. Head Neck 1999;21: 346-54.
  • Phelan JT, Sherer W, Mos P.Malignant smooth-muscle tumors (leiomyosarcomas) of soft tissue origin. N Engl J Med 1962;266:1027-30.
  • Pisters PWT, Leung DHY, Woodruff J, Shi W, Brennan MF. Análisis of prognostic in 1041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996; 14:1679-89.
  • Rice DH, Stanley RB. Surgical therapy of tumors of the nasal cavity, ethmoid sinus and maxillary sinus. In Thawley SE, Panje WR, Batsakis JG, Lindberg RD (eds). Comprehensive Management of head and neck tumors 2nd ed, W B Saunders Company, Philadelphia, USA, 558-81.1999.
  • Santa Cruz Ruiz S, Del Cañizo Álvarez A, De Prado Sanjosé MM, Flores Corral T. Leiomiosarcoma nasal. Acta Otorrinolaringol Esp 2000; 51(6):515-7.
  • Snowden RT, Osborn FD, Wong FSH, Sebelik ME. Superficial leiomyosarcoma of the head and neck: Case report and review of the literature. Ear Nose Throat J 2001;80: 449-53.
  • Som PM, Brandwein M. Sinonasal cavities: Inflamatory disease, tumor, fractures and postoperative findings. In Som PM, Curtin HD (eds): Head and Neck Imaging, 3rd ed, Mosby, St Louis, 126-318, 1996.
  • Tokiya R, Imajo Y, Yoden E, Hiratsuka J, Kabatake M, Gyoten M, Imai S, Kajihara Y. A long-term survivor of leiomyosarcoma around the right side of the base of the skull: Effective radiotherapy combined with intra-arterial chemotherapy. Int J Clin Oncol 2002;7:57-61.
  • Tokiya R, Imajo Y, Yoden E, Hiratsuka J, Kobatake M, Gyoten M, Imai S, Kahihara Y. A long-term survivor of leiomyosarcoma around the right side of the base of the skull: Effective radiotherapy combined with intraarterial chemotherapy. Int J Clin Oncol 2002; 7 (1): 57-61.
  • Zagars GK, Ballo MT, Pisters PWT, Pollock RE, Patel SR, Benjamín RS, Evans HL. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy. An analysis od 1225 patients. Cancer 2003;97: 2530-43.
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