Miopatías inflamatorias idiopáticas
- Turrión Nieves, Ana Isabel
- Martín Holguera, Rafael
- Sánchez Atrio, Ana
- Moruno Cruz, Henry
ISSN: 0304-5412
Year of publication: 2013
Issue Title: Enfermedades del sistema inmune (VI): vasculitis y miopatías inflamatorias
Series: 11
Issue: 33
Pages: 2040-2047
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Abstract
Inflammatory myopathies are diseases with autoimmune component that present with muscle weakness, elevated muscle enzymes and myopathic pattern on electromyography. May occur in isolation or associated with other autoimmune diseases overlap syndromes or related neoplasms. For histology are classified into 4 types which are dermatomyositis, polymyositis, inclusion body myositis and immune-mediated necrotizing myopathy. The first and last feature a humoral component (B-cell and complement) while polymyositis and inclusion body myositis would be mediated by T-cells. In forms with humoral component is important to rule out its association with neoplastic processes. Treatment of these patients is based on the use of steroids and immunosuppressants. IVIG is used in severe forms. The use of biological drugs such as rituximab appears promising in forms mediated humoral immunity.