Protocolo diagnóstico y tratamiento de la osteomalacia

  1. Canabal, G. Manzano
  2. Vega, M.E. Acosta de la
  3. Calleja, C. Hidalgo
  4. Morales, C. Montilla
  5. del Pino-Montes, J.
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2018

Issue Title: Enfermedades óseas Osteoporosis. Paget óseo. Síndrome de dolor regional complejo

Series: 12

Issue: 60

Pages: 3542-3546

Type: Article

DOI: 10.1016/J.MED.2018.06.024 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Osteomalacia is a bone mineralisation defect in mature bone. The most common cause is a severe vitamin D deficiency, which in our environment occurs in situations of social exclusion or malabsorption. It is generally clinically asymptomatic, but there can be bone pain and muscle weakness. Tetany is observed in cases with severe hypocalcaemia. In very evolved forms, x-ray shows biconcave vertebrae or deformity of the long bones with Looser's pseudofractures. When there is a vitamin D deficiency, serum levels of 25(OH)2D, calcium, phosphorus descend, while alkaline phosphatase and PTH levels rise. Diagnosis is confirmed by bone histomorphometry. It is important to treat the cause of osteomalacia, if possible. A vitamin D deficiency is corrected by ensuring adequate intake of calcium. Occasionally very high doses of vitamin D will be required.

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Funding information

Pathogenesis and diagnostic criteria for rickets and osteomalacia–proposal by an expert panel supported by the Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research, and the Japan Endocrine Society

Funders

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Data source: Dialnet