Diseño y validación de una ecuación para la dosificación inicial de vancomicina en pacientes ancianos

  1. PASTOR LOZANO, Alicia
  2. MARTÍN SUÁREZ, Ana María 2
  3. García González, David
  4. ARADANUY ANDUJAR, Ramón 3
  5. MACIAS NUÑEZ, Juan Florencio 4
  6. CALVO, María Victoria 1
  1. 1 Servicio de Farmacia Complejo Asistencial Universitario de Salamanca
  2. 2 Departamento Ciencias Farmacéuticas, Universidad de Salamanca
  3. 3 Departamento de Estadística Facultad de Ciencias Universidad de Salamanca
  4. 4 Servicio de Nefrología Complejo Asistencial Universitario de Salamanca5
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Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2018

Volume: 3

Issue: 1

Pages: 111-119

Type: Article

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Abstract

Elderly patients have unique characteristics that make dosing drugs a necessity in many cases, especially in those excreted by renal function, as in the case of vancomycin. HUGE value is a tool for differentiating the presence or absence of chronic kidney disease in patients older than 70 years. The objective was to obtain an equation based on the HUGE value to predict the initial dose of vancomycin in patients older than 70 years. The equation was designed retrospectively in 70 patients and it was validated in 40 patients in comparison with the PKS® method (Pharmacokinetic System, Abbott) based on creatinine clearance. The submitted equation, HUGE-VAN, was obtained by multiple linear regression:It is recommended to administer vancomycin every 12 hours except that HUGE is greater than 7.34 which is recommended once daily. The values obtained in the validation phase equalize or improve PKS® method. HUGE-VAN considers multiple clinical data and not merely the estimated value of glomerular filtration rate. For this reason, HUGE-VAN is presented like a promising alternative for the vancomycin dosing in patients older than 70 years. 

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