Detección de la infección por citomegalovirus congénito en neonatos que no pasan el cribado auditivo universal

  1. José Ignacio BENITO-OREJAS
  2. Fernando BENITO-GONZÁLEZ
  3. Fernando GARCÍA-VICARIO
  4. Gerardo MARTÍN-SIGÜENZA
  5. María REY-MARCOS
  6. María Luisa SERRANO-MADRID 1
  7. Elisa GIL CARCEDO-SAÑUDO
  8. Jesús SAN ROMÁN-CARBAJO
  9. Laura CURIESES-BECERRIL
  10. Víctor Manuel MARUGÁN-ISABEL 2
  1. 1 Complejo Asistencial de Soria
    info

    Complejo Asistencial de Soria

    Soria, España

  2. 2 Hospital Virgen de la Concha
    info

    Hospital Virgen de la Concha

    Zamora, España

    ROR https://ror.org/02bhk3j29

Revue:
Revista ORL

ISSN: 2444-7986,  2444-7986

Année de publication: 2019

Volumen: 10

Volumen: 4

Pages: 253-261

Type: Article

DOI: 10.14201/ORL.21117 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

D'autres publications dans: Revista ORL

Résumé

Introduction: Given the importance of early antiviral treatment in infants with sensorineural hearing loss secondary to congenital cytomegalovirus infection (cCMV), we submit a protocol for early diagnosis of cCMV according to the outcome of universal newborn hearing screening using automated auditory brainstem responses (AABR) (targeted CMV screening). Material and methods: Based on current knowledge provides by literature, we elaborate an action algorithm agreed between the coordinators of the Early Hearing Detection and Intervention program in Castilla y León (Spain). Results: If the first AABR test is a refer result for one or both ears, we request the identification of the viral genome by PCR in a urine sample within 15 days. The confirmation of uni or bilateral sensorineural hearing loss, allows the beginning of the antiviral treatment, before the first month of life. Discussion: Universal screening of cCMV enables monitoring of all infected infants, identifying cases of late-onset/progressive hearing loss sooner; but in the presence of an unknown cause- sensorineural hearing loss from the first two weeks of life, efforts must be made to rule out cCMV infection, although it is more complicated under these conditions. Conclusion: The inclusion of cCMV diagnosis into neonatal hearing screening program, will allow early detection of congenital infection in some infants, improving their quality of life.

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