2-oxa y 6-oxanortropanosproductos naturales, síntesis y actividades biológicas

1. Alejandro M. Roncero ¹
2. Alberto Esteban ¹
3. Mª Angeles Castro ¹
4. D. Díez ¹

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More publications in: Anales de Química de la RSEQ

Abstract

Tropane core is found in many natural compounds as Solanaceae alkaloids, atropine or scopolamine. In relation with this skeleton, nor-tropane core appears in calystegines, which are polyhydroxylated alkaloids isolated from rhizomes of plants as Calystegia sepium or Convolvulus arvensis. These compounds show an important glucosidase-inhibitory activity, inhibiting β-glucosidase and α-galactosidase among others. These enzymes are altered in diverse metabolic pathologies as the Gaucher’s disease. Synthesis of oxygenated analogues of these compounds are arising due to these pharmacological properties. In this review, 2-oxa- and 6-oxa-nortropanes last related researches are shown.

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