Estudio del factor de crecimiento del endotelio vascular (VEGF) y del factor de crecimiento fibroblástico básico (bFGF) en la patología benigna y maligna de la próstata.

Abstract

Introduction: The evidence that the growth and progression of prostate cancer is angiogenesis dependent has been shown for the correlation among the neovascularization in prostate weaving tumoral with the increment of the density vascular and the expression of the angiogenic growth factors. There are evidences that support the intervention of growth factors VEGF and bFGF in the development and progression of prostate cancer. Objectives: Verifying if relation between the serum levels of VEGF and urinary levels of bFGF with the prostate harmful and benign pathology, at the moment of the initial diagnosis. Determining if relation between the serum levels of VEGF and the urinary levels of bFGF with the serum levels of PSA, age, tumoral clinical stage, degree of Gleason and presence of metastasis, at the moment of the initial diagnosis, as well as with the mortality specific cancer in the eight first years of monitoring. Material and method: It was quantified, by means of techniques of ELISA, VEGF in serum and bFGF in urine of 71 patients with indication of prostate biopsy by suspects of neoplasia. They were grouped according to the result of the biopsy in group A: 23 patients with prostate adenocarcinoma, group B: 48 patients with benign hiperplasia of prostate. Results: There were appreciated differentiate significant between the serum values of VEGF and the presence of metastasis. Themselves they were not observed you differentiate significant between the serum values of VEGF and urinary of bFGF with both groups of study neither with the age of the patients, PSA, clinical stage, degree of Gleason and mortality specific cancer. Conclusions: High levels of VEGF in serum associate patients with metastatic prostate cancer. The quantification of the levels of VEGF can be useful like scoreboard of illness disseminated and can add additional pronostic information to it provided by the degree of Gleason, clinical stadium and serum PSA.