Eficacia y seguridad de los nuevos tratamientos en pacientes diagnosticados de hepatitis Ctelaprevir y boceprevir

  1. GONZALEZ, Marta 1
  2. GUTIERREZ, Esperanza 1
  3. SAEZ, Mónica 1
  4. ORTEGA, Luis 1
  5. ORTIZ DE URBINA, Juan José 1
  1. 1 Complejo Asistencial Universitario de León
    info

    Complejo Asistencial Universitario de León

    León, España

    ROR https://ror.org/05gn84d31

Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2016

Volume: 1

Issue: 2

Pages: 109-116

Type: Article

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More publications in: Farmajournal

Abstract

Hepatitis C is a disease caused by a virus that may have different genotypes. The standard treatment of peginterferon plus ribavirin, is added boceprevir (BCP) or telaprevir (TVP), direct-acting antiviral agents. The aim of this study is to evaluate the effectiveness through and the safety through the side effects of drugs. This is an observational retrospective study conducted in patients with standard treatment BCP or TVP in 2012 at the Hospital of Leon. The sample of 27 patients, 7 of them stopped the treatment post lead-in. Of the remaining 20, 20% stopped it, 25% due to adverse reactions and 75% because of the HCV RNA or stopping rules. The remaining 80% (16 patients), 68.75% achieved sustained virologic response while 31.25% relapsed. It is appreciated a better response in relapsed patients with genotype 1a and phenotype CT. With respect to side effects, the most frequent were gastrointestinal disorders, rash, weight loss, neutropenia, anemia, thrombocytopenia and psychiatric disorders. The complexity of these treatments requires a multidisciplinary monitoring of patients.

Bibliographic References

  • Agencia española de Medicamentos y Productos Sanitarios [internet]. Madrid: Agencia Española del Medicamento y Productos Sanitarios; 2011 [acceso 29 de abril de 2014]. Disponible en: http://www.aemps.es.
  • Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1207-17
  • Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH et al. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med. 2011;364(25):2405-16
  • Pellicer M, Lebrero A, Fernández-Pacheco M, Matoses SM, Herranz C, Luque R. Efectividad y seguridad del tratamiento de la hepatitis crónica c basado en triple terapia. Farm Hosp. 2013;37(Suppl 1): 178
  • Ubago Pérez R, Castillo Muñoz MA, Navarro Caballero JA, Márquez Peláez S. Inhibidores de la proteasa (boceprevir y telaprevir) en el tratamiento de pacientes monoinfectados por el VHC: eficacia, seguridad y eficiencia comparada [Internet]. Sevilla: Agencia de Evaluación de Tecnologías Sanitarias, 2012. Informe 1/2012. URL: www.juntadeandalucia.es/salud/orgdep /AETSA
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