Estudio de ncRNA en varones con cáncer de mama

  1. Díez Castro, David 1
  2. Ovejero Sánchez, María 1
  3. González Sarmiento, Rogelio 1
  1. 1 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

Zeitschrift:
Farmajournal

ISSN: 2445-1355

Datum der Publikation: 2021

Ausgabe: 6

Nummer: 1

Seiten: 27-37

Art: Artikel

DOI: 10.14201/FJ2021612737 DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Farmajournal

Zusammenfassung

Male breast cancer (BC) is a rare disease accounting for less than 1% of all BC detected. For this reason, it would be important to find ways to prevent this kind of cancer, to know how it develops in men and if there is any genetic predisposition to have BC. We know that noncoding RNA (ncRNA) are involved in female breast cancer but there is no information about their role in males. In this paper we try to find if some ncRNA have implications in male BC. Specifically, we have studied some single nucleotide polymorphisms of the genes encoding for mir-146A, mir-196A2, mir-499A and long noncoding RNA, HotAIR. The technique used was genotyping with taqman probe, that allows to discriminate between different polymorphisms. The genetic counsil of cancer research center provides us with the study population. The preliminary results showed that the allele C of the polymorphism with rs2910164 of the mir-146A gene and the genotype CA of the polymorphism with rs1899663 of the HotAIR gene could protect males from developing BC.

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Fuente de los datos: Dialnet