Valoración de la efectividad del ácido hialurónico en la cicatrización de zonas donantes

Zusammenfassung

Partial skin graft is one of the most commonly used techniques in plastic surgery. There is currently no consensus on the proper treatment of donor areas. This lack of evidence forces empirical treatments based on preferences or customs that consume resources and delay healing. Our study can help establish a homogeneous procedure in addressing these wounds in order to speed up the healing period, and reduce the risks of infection and thus provide an increase in the quality of life of patients The role of hyaluronic acid in healing is paramount, allowing the repair of the extracellular matrix, and collaborating in processes of migration, proliferation and cell differentiation. By adding it to nanocrystalline silver dressings that are good antimicrobials and metalloproteinase reducers could speed up the healing process. We conducted a prospective case-control study with 52 patients who required partial skin grafting. The donor areas were cured with nanocrystalline silver dressing in all cases, adding to half of these dressings, 5 ml of 1% hyaluronic acid in the form of sodium salt. We value in the safety and effectiveness of epithelialization in both scenarios. The results are suggested that the addiction of hyaluronic acid in silver dressings is safe and promotes the epithelialization of donor areas. They reflect an average epithelialization by areas of 0.95 x 0.1 in areas treated with hyaluronic acid versus 0.88 x 0.11 (p .0.005) in untreated areas. Regarding the perimeters, we found averages of 0.78 x 0.83 in areas of AH and 0.58 x 0.62,( p s 0.005)In addition to favoring an analgesic effect with changes in visual analogue scale (EVA) and find a score on the XI mid-Vancouver scale in hydrated areas with AH of 5.69 x 2.34 and 4.44 x 2.05 in untreated areas. The difference was significant (p <0.005) for all subparameters (flexibility, height, and pigmentation.) except for vascularization. In conclusion, we can say, that hyaluronic acid added to silver would accelerate the healing of donor areas, providing better comfort with dressing changes and better long-term aesthetic result.