Enfermedad venosa aguda

  1. Lozano Sánchez, F.S. 1
  2. Salvador Calvo, R. 1
  3. Velasco Hernández, P. 1
  4. Peña Cortés, R. 1
  1. 1 Servicio de Angiología y Cirugía Vascular, Hospital Universitario de Salamanca, España Salamanca, Departamento de Cirugía, Universidad de Salamanca, Salamanca, España
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2021

Issue Title: Enfermedades cardiovasculares (V)

Series: 13

Issue: 39

Pages: 2258-2269

Type: Article

DOI: 10.1016/J.MED.2021.08.002 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Acute venous disease includes deep vein thrombosis, superficial vein thrombosis and venous trauma. We will deal only with the first, which is interesting due to its frequency, severity (pulmonary embolism), recurrence, sequelae (post-thrombotic syndrome) and social and economic implications. It is a multifactorial disease. Virchow's triad: parietal (trauma), haemodynamic (stasis) and blood (hypercoagulability) factors. Clinical symptoms (pain and oedema) are not helpful for diagnosis. An algorithm including a clinical predictive test, D-dimer, and echo-Doppler (test of choice) is an effective and efficient diagnostic strategy. Phlebography and/or computerised angiotomography are reserved for borderline cases. Anticoagulation is the method of choice in the acute and secondary prevention phase. In these phases, direct oral anticoagulants compete with low molecular weight heparins. The duration of anticoagulation, timing of discontinuation and decision to extend treatment must be considered to avoid relapses and complications. Outpatient treatment is an aspect of great clinical, social, and economic relevance, where patient selection is very important. Other treatments (catheter fibrinolysis, interruption of the inferior vena cava etc.) have very specific indications.

Bibliographic References

  • Meissner MH, Eklof B, Lohr JM, Lurie F, Kistner R, Wakefield TW. Preface: acute and chronic venous disease. Current status and future directions. J Vasc Surg. 2007;46Suppl S:1S-3S.
  • Meissner MH, Wakefield TW, Ascher E, Caprini JA, Comerota AJ, Eklof B. Acute venous disease: venous thrombosis and venous trauma. J Vasc Surg. 2007;46SupplS:25S-53S.
  • Lozano Sánchez FS. Isquemia arterial crónica de las extremidades. Capítulo XV. En: Lozano Sánchez FS, editor. Cuadernos de patología vascular. Vol. 3. Madrid: Arán ed.; 2006.
  • Lozano Sánchez FS, Rubio Taboada C, González Porras JR. Venous thrombosis associated with venous compression syndromes. Med Clin (Barc). 2020;154(10):406-11.
  • Lozano Sánchez FS, González Porras JR, Torres Hernández JA, Carnicero Martínez JA. La trombosis venosa superficial ¡no es una enfermedad benigna! Angiología. 2020;72(3):135-44.
  • Haas S. European consensus statement on the prevention of venous thromboembolism. European Consensus Conference, Windsor, U.K., November, 1991. Blood Coagul Fibrinolysis. 1993;4Suppl1:S5-8.
  • Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG. VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost. 2007;98(4):756-64.
  • Guijarro R, Montes J, Sanromán C, Monreal M; RIETE Investigators. Venous thromboembolism in Spain. Comparison between an administrative database and the RIETE registry. Eur J Intern Med. 2008;19(6): 443-6.
  • Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol. 2015;12(8):464-74.
  • Lozano Sánchez F, Areitio Aurtena Bolumburu DA, González Porras JR. Nota histórica sobre la trombosis venosa. Salamanca: Ed. Kadmos; 2015.
  • Lozano Sánchez FS, González Porras JR, Díaz Sánchez S, Marinel Lo Roura J, Sánchez Nevarez I, Carrasco EC, et al; C-VIVES Study investigators. Negative impact of deep venous thrombosis on chronic venous disease. Thromb Res. 2013;131(4):e123-6.
  • Lozano F, Suárez C, Ruiz N, Barja P, Aristegui R. Validación de la versión española del cuestionario VEINES-QoL/Sym para pacientes con trombosis venosa profunda. Rev Esp Econ Salud. 2016;11:682-91.
  • Hyers TM. Venous thromboembolism. Am J Respir Crit Care Med. 1999;159(1):1-14.
  • MacDougall DA, Feliu AL, Boccuzzi SJ, Lin J. Economic burden of deepvein thrombosis, pulmonary embolism, and post-thrombotic syndrome. Am J Health Syst Pharm. 2006;63(20)Suppl6:S5-15.
  • Jiménez D, Yusen RD. Prognostic models for selecting patients with acute pulmonary embolism for initial outpatient therapy. Curr Opin Pulm Med. 2008;14(5):414-21.
  • Eichinger S, Heinze G, Jandeck LM, Kyrle PA. Risk assessment of recu-rrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model. Circulation. 2010;121(14): 1630-6.
  • Tosetto A, Iorio A, Marcucci M, Baglin T, Cushman M, Eichinger S. Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH). J Thromb Haemost. 2012;10(6):1019-25.
  • Palareti G. Recurrent venous thromboembolism: Whats is the risk and how to prevent it. Scientifica. 2012:1-17.
  • Kahn SR, Shrier I, Julian JA, Ducruet T, Arsenault L, Miron MJ. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med. 2008;149(10):698-707.
  • Ten Cate Hoek AJ, Ten Cate H, Tordoir J, Hamulyák K, Prins MH. Individually tailored duration of elastic compression therapy in relation to incidence of the postthrombotic syndrome. J Vasc Surg. 2010;52(1): 132-8.
  • Lozano F. Actualización en trombosis venosa profunda que afecta a las extremidades inferiores: diagnóstico. Angiologia. 2003;55(5):476-87.
  • Lozano F. Diagnóstico de la trombosis venosa profunda (Capítulo 12). En: Rocha E, Lecumberry R, editors. Enfermedad tromboembólica venosa. Resumen y comentarios a la 9ª Conferencia ACCP (2012). Madrid: Grupo Acción Médica; 2013. p. 169-83.
  • Wheeler HB, Anderson Jr FA. Diagnostic for deep vein thrombosis. Hae-mostasis. 1995;25(1-2):6-26.
  • Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L. Value of assessment of pretest probability of deep vein thrombosis in clinical management. Lancet. 1997;350(9097):1795-8.
  • Wells PS. Diagnosis of venous thromboembolism: 20 years of progress. Ann Intern Med. 2018;168(2):131-40.
  • Lee JH, Lee SH, Yun SJ. Comparison of 2-point and 3-point point of care ultrasound techniques for deep vein thrombosis at the emergency department: A meta analysis. Medicine (Baltimore). 2019;98(22):e15791.
  • Kraaijpoel N, Carrier M, Le Gal G, McInnes MDF, Salameh JP, McGrath TA. Diagnostic accuracy of three ultrasonography strategies for deep vein thrombosis of the lower extremity: A systematic review and meta analysis. PLoS One. 2020;15(2):e0228788.
  • Langan EM, Coffey CB, Taylor SM, Snyder BA, Sullivan TM, Cull DL. The impact of the development of a program to reduce urgent (off hours) venous duplex ultrasound studies. J Vasc Surg. 2002;36(1):132-6.
  • Rocha E, Lozano FS, Jiménez D, Lecumberri R. Tratamiento antitrombótico de la enfermedad tromboembólica venosa (Capítulo 13). En: Rocha E, Lecumberry R. Enfermedad tromboembólica venosa. Resumen y comentarios a la 9ª Conferencia ACCP (2012). Madrid: Grupo Acción Médica; 2013. p. 185-219.
  • Kearon C, Akl EA, Ornelas J, Blaivas A, Jiménez D, Bouna-meaux H. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315-52.
  • Witt DM, Nieuwlaat R, Clark NP, Ansell J, Holbrook A, Skov J. American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy. Blood Adv. 2018;2(22):3257-91.
  • Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A. American Society of Hematology 2020 guidelines for manage-ment of venous thromboembolism: treatment of deep vein throm-bosis and pulmonary embolism. Blood Adv. 2020;4(19):4693-738.
  • Imberti D, Pomero F, Mastroiacovo D. Direct oral anticoagulants for extended treatment of venous thromboembolism: insights from the EINSTEIN CHOICE study. Blood Transfus. 2020;18(1):49-57.
  • Kirkilesis GI, Kakkos SK, Tsolakis IA. Editor’s choice-A systematic review and meta analysis of the efficacy and safety of anticoagulation in the treatment of venous thromboembolism in patients with cancer. Eur J Vasc Endovasc Surg. 2019;57(5):685-701.
  • Li A, Garcia DA, Lyman GH, Carrier M. Direct oral anticoagulant (DOAC) versus low molecular weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis. Thromb Res. 2019;173:158-63.
  • Moik F, Posch F, Zielinski C, Pabinger I, Ay C. Direct oral anticoagulants compared to low molecular weight heparin for the treatment of cancer associated thrombosis: Updated systematic review and meta analysis of randomized controlled trials. Res Pract Thromb Haemost. 2020;4(4): 550-61.
  • Lozano FS, Valverde S, Rubio C, Peña R, Salvador R, Carnicero JA. Diagnóstico y tratamiento de la trombosis venosa profunda distal aislada. En: San Norberto EM, editor, coord. Guías SOCLACIVAS. 2ª ed. Valladolid: Mata Digital; 2018. p. 47-60.
  • Othieno R, Okpo E, Forster R. Home versus inpatient treatment for deep vein thrombosis. Cochrane Database Syst Rev. 2018;1(1):CD003076.
  • Lozano F, Trujillo Santos J, Barrón M, Gallego P, Babalis D, Santos M. the RIETE Investigators. Home versus in-hospital treatment of outpatients with acute deep venous thrombosis of the lower limbs. J Vasc Surg. 2014;59(5):1362-7.
  • Trujillo Santos J, Lozano F, Lorente MA, Adarraga MD, Hirmerova J, Del Toro J. A full list of RIETE investigators is given in the appendix. A prognostic score to identify low-risk outpatients with acute deep vein thrombosis in the lower limbs. Am J Med. 2015;128(1):90.e9-15.