Identificación de la actividad hipotensora del extracto etanólico de Solanum tuberusom en ratas
- Guerrero, Mario
- Carrón, Rosalia
- Martín, María
ISSN: 1909-6356, 0034-7418
Year of publication: 2003
Volume: 32
Issue: 1
Pages: 30-36
Type: Article
More publications in: Revista Colombiana de Ciencias Químico-Farmacéuticas
Abstract
Hypotensive and vasorelaxant effects of the ethanolic extract of Solanum tuberosum, in anaesthetized rats and isolated aorta rings were investigated. Intravenous injections of the bark extract (5-15 mg/kg) produced a dose-dependent decreasing in mean arterial pressure and heart rate in spontaneously hypertensive rats (SHR) as well as Wistar rats. Furthermore, the bark extract has produced a vasorelaxant response (in a concentration dependent manner, IC50: 3.9E-4 g/ml), in intact Wistar rat aortic rings, previously contracted by KCl