Identificación de la actividad hipotensora del extracto etanólico de Solanum tuberusom en ratas

  1. Guerrero, Mario
  2. Carrón, Rosalia
  3. Martín, María
Journal:
Revista Colombiana de Ciencias Químico-Farmacéuticas

ISSN: 1909-6356 0034-7418

Year of publication: 2003

Volume: 32

Issue: 1

Pages: 30-36

Type: Article

More publications in: Revista Colombiana de Ciencias Químico-Farmacéuticas

Abstract

Hypotensive and vasorelaxant effects of the ethanolic extract of Solanum tuberosum, in anaesthetized rats and isolated aorta rings were investigated. Intravenous injections of the bark extract (5-15 mg/kg) produced a dose-dependent decreasing in mean arterial pressure and heart rate in spontaneously hypertensive rats (SHR) as well as Wistar rats. Furthermore, the bark extract has produced a vasorelaxant response (in a concentration dependent manner, IC50: 3.9E-4 g/ml), in intact Wistar rat aortic rings, previously contracted by KCl