Antiseptic capacity of 0.05% chlorhexidine digluconate and 0.05% cetylpyridinium chloride. A prospective and microbiological clinical study

Abstract

Introduction: The aim of this study was to evaluate the clinical and microbiological efficacy of an oral rinse (colutory) containing 0.05% chlorhexidine digluconate (CHX) and 0.05% cetylpyridinium chloride (CPC) when compared to another rinse without antiseptic properties, used as adjuvants to oral hygiene methods. Material and methods: Using spectrophotometry, a microbiological study was conducted to evaluate the capacity of each rinse to inhibit the formation and adhesion of Streptococcus oralis bacterial biofilm, followed by a randomized and double-blind clinical trial conducted on a sample of 48 patients randomly assigned to either rinse. • Oral Rinse A: 0.05% CHX, 0.05% CPC and 0.14% zinc lactate • Oral Rinse B: 0.10% permethol and 0.50% provitamin B5. The plaque index (PI), modified gingival index (MGI), and sulcus bleeding index (SBI) were evaluated at one and three months. Results: The 0.05% CHX and 0.05% CPCbased mouth rinse showed a high capacity to inhibit formation (P=0.013) and adhesion (P=0.001) of bacterial biofilm. Statistically significant differences in inter-group PI were observed at three months of observation (P<0.001). Differences in the MGI were also observed at one month (P=0.034) and three months of observation (P<0.001); and in the SBI at one month (P=0.004) and at three months of observation (P=0.002). Conclusions: The 0.05% CHX and 0.05% CPC-based colutory.