Biotechnological applications of bacterial cellulases

  1. Menendez, Esther 1
  2. Garcia-Fraile, Paula 2
  3. Rivas, Raul 13
  1. 1 Universidad de Salamanca

    Universidad de Salamanca

    Salamanca, España


  2. 2 Institute of Microbiology ASCR, Laboratory of Fungal Genetics and Metabolism, Prague. Czech Republic
  3. 3 Instituto de Recursos Naturales y Agrobiología de Salamanca

    Instituto de Recursos Naturales y Agrobiología de Salamanca

    Salamanca, España


AIMS Bioengineering

ISSN: 2375-1495

Year of publication: 2015

Volume: 2

Issue: 3

Pages: 163-182

Type: Review

DOI: 10.3934/BIOENG.2015.3.163 WoS: WOS:000215257500005 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: AIMS Bioengineering


Cited by

  • Web of Science Cited by: 29 (21-09-2023)
  • Dimensions Cited by: 44 (24-03-2023)


(Data updated as of 24-03-2023)
  • Total citations: 44
  • Recent citations: 19
  • Field Citation Ratio (FCR): 6.18


Cellulases have numerous applications in several industries, including biofuel production, food and feed industry, brewing, pulp and paper, textile, laundry, and agriculture.Cellulose-degrading bacteria are widely spread in nature, being isolated from quite different environments. Cellulose degradation is the result of a synergic process between an endoglucanase, an exoglucanase and a,β-glucosidase. Bacterial endoglucanases degrade ß-1,4-glucan linkages of cellulose amorphous zones, meanwhile exoglucanases cleave the remaining oligosaccharide chains, originating cellobiose, which is hydrolyzed by ß-glucanases. Bacterial cellulases (EC are comprised in fourteen Glycosil Hydrolase families. Several advantages, such as higher growth rates and genetic versatility, emphasize the suitability and advantages of bacterial cellulases over other sources for this group of enzymes. This review summarizes the main known cellulolytic bacteria and the best strategies to optimize their cellulase production, focusing on endoglucanases, as well as it reviews the main biotechnological applications of bacterial cellulases in several industries, medicine and agriculture.

Funding information

RR would like to thank Junta de Castilla y Leon (Regional Government, Grant SA169U14) and MINECO (Central Government, Grant AGL2011-29227). EM acknowledges MINECO (Central Government, Grant AGL2011-29227 and AGL2013-48098-P) for funding her position. PGF is thankful to the European Social Fund and the state budget of the Czech Republic (CZ.1.07/2.3.00/30.0003), which funds her position.


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