Hemorragia espontánea de origen incierto

  1. Elvira-Laffond, Ana 1
  2. González-Calle, David 1
  3. Hernández-Hidalgo, Miguel 1
  4. Hernández-Martos, Ángel Víctor 1
  5. Sánchez Ledesma, María 2
  1. 1 Servicio de Cardiología. Complejo Asistencial Universitario de Salamanca. Salamanca. España
  2. 2 Servicio de Medicina Interna. Complejo Asistencial Universitario de Salamanca. Salamanca. España
Revista:
Revista Española de Casos Clínicos en Medicina Interna (RECCMI)

ISSN: 2530-0792

Ano de publicación: 2020

Título do exemplar: Spanish Journal of Case Records in Internal Medicine

Volume: 5

Número: 2

Páxinas: 74-77

Tipo: Artigo

DOI: 10.32818/RECCMI.A5N2A7 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Revista Española de Casos Clínicos en Medicina Interna (RECCMI)

Resumo

Acquired hemophilia A is a rare disease caused by autoantibodies targeting coagulation factor VIII. It should be suspected in case of spontaneous bleeding and extended aPTT. We present an 85-year-old male patient with retroperitoneal hematoma and prolonged aPTT. Factor VIII activity is determined, which is significantly reduced. The patient begins treatment, with excellent clinical response. This is an illustrativeexample of this unknown disease, which may provide its better understanding and management of these patients.

Referencias bibliográficas

  • Knoebl P, Marco P, Baudo F, et al. Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost 2012;10:622–31.
  • Collins PW, Hirsch S, Baglin TP, et al. Acquired haemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organisation. Blood. 2008; 190:1870-7.
  • Delgado J, Jimenez-Yuste V, Hernandez-Navarro F, Villar A. Acquired haemopholia: review and meta-analysis focused on tjerapy and prognostic factors. Br J Haematol. 2003; 121:21-35.
  • Tiede A, Werwitzke S, Scharf RE. Laboratory diagnosis of acquired haemophilia A: limitations, consequences and challenges. Semin Throm Hemost. 2014; 40:803-11.
  • Collins P, Baudo F, Huth-Kuhne A, et al. Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 2010;3:161.
  • Huth-Kuhne A, Baudo F, Collins P, et al. International recommendations on the diagnosis and treatment of patients with acquired haemophilia A. Haematologica. 2009; 94:566-75.
  • Kessler CM, Knöbl P. Acquired haemophilia: an overview for clinical practice. Eur J Haematol. 2015 Dec. 95 Suppl 81:36-44.
Fonte de datos: Dialnet