La hiperqueratosis citológica como parámetro indirecto de la infección por el virus del papiloma humano

  1. Ángel García Iglesias 1
  2. Silvia García Valle 1
  3. Joaquín López Marcos 1
  4. Victoria Martín Gómez 1
  5. David Holgado Sánchez 1
  1. 1 Hospital Universitario de Salamanca

    Hospital Universitario de Salamanca

    Salamanca, España


Revista Electrónica de Biomedicina

ISSN: 1697-090X

Year of publication: 2009

Issue: 2

Pages: 49-55

Type: Article

More publications in: Revista Electrónica de Biomedicina


Introduction: Hyperkeratosis is an epithelial lesion with a histology that consists of a thickening of the cells of the stratum corneum that lack nuclei. There are some factors that can cause hyperkeratosis, such as a reaction of the epithelium to local, mechanical, chemical or infectious stimuli. The most common cause is the human papillomavirus. Objetives: We want to establish the relation between the presence of hyperkeratosis in the cytological screening test and a possible relation with the infection of human papillomavirus. Materials and methods: We studied 2372 cytological samples that were taken during one year in the Unit of Gynaecology and Obstetrics of the University Hospital of Salamanca. The age range of the patients was between 16 and 65 years of age. The cytological sample was taken with a Pap smear and it was kept in a liquid medium. All samples with cytological alterations were rejected and 1125 studies were considered negative. From these, 316 samples showed hyperkeratosis. All patients who presented that condition underwent a colposcopic study, and the HPV was detected by PCR. Results: In 27% of the cases, the PCR test for HPV was negative, and it was positive in the rest of them. A PPV of 72% and a NPV of 39% were established. Sensitivity value was 46% and specifity was 81%.

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