Description of the fractional excretion of phosphorus and fractional excretion of uric acid curves related to progressive decrease of glomerular filtration rate in chronic kidney disease patients
- Carlos G. Musso 1
- Sergio Terrasa
- Maria Risso 1
- Sofía Sallustio 1
- Valentin Sueiro 1
- Jose Jauregui
- Javier Deira
- Juan F. Macías Núñez 2
- 1 Instituto Universitario del Hospital Italiano de Buenos Aires
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2
Universidad de Salamanca
info
ISSN: 1697-090X
Datum der Publikation: 2017
Nummer: 3
Seiten: 40-47
Art: Artikel
Andere Publikationen in: Revista Electrónica de Biomedicina
Zusammenfassung
It is a widely known fact that in the patient with chronic kidney disease, as the glomerular filtration rate decreases, the fractional excretion of electrolytes and nitrogenous substances increases. However, the curve that graphs this correlation for the handling of phosphorus and uric acid in this population has not been described yet. The concern arose to describe the curve that reflects the progressive change in the fractional excretion of two substances of eminent proximal tubular management, one by tubular reabsorption (phosphorus) and the other by tubular secretion (uric acid), given that these curves could be used in clinical practice to evaluate how tubular functions are in a patient with chronic kidney disease. Material and Method: In 32 patients with different stages of chronic kidney disease secondary to glomerular causes (stages I to V), creatinine clearance (CC) and fractional excretion (FE) of phosphorus and uric acid were obtained. Then, the correlation between CC and both FEs was evaluated. Results: Spearman correlation between CC and FE of phosphorus: - 0.8 (p <0.001) and between CC and FE of uric acid: - 0.4 (p = 0.005). Conclusion: A significant and inverse correlation was found between the value of creatinine clearance and the fractional excretion of phosphorus and uric acid in patients suffering from chronic kidney disease.