Efecto del consumo de tabaco en las enfermedades inflamatorias intestinalesmetaanálisis

  1. Díez, Cira 1
  2. Fernández-Gómez, María José 1
  3. Martín-Vallejo, Javier 1
  1. 1 Universidad de Salamanca
    info

    Universidad de Salamanca

    Salamanca, España

    ROR https://ror.org/02f40zc51

Journal:
Farmajournal

ISSN: 2445-1355

Year of publication: 2022

Volume: 7

Issue: 2

Pages: 19-28

Type: Article

DOI: 10.14201/FJ2022721928 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Farmajournal

Abstract

Ulcerative colitis and Crohn’s disease are the two main types of inflammatory bowel disease and affect the gastrointestinal tract in a chronic and immune-mediated manner. They arise from the interaction of the immune system and the intestinal microbiota with genetic and environmental factors, being tobacco one of the most influential. Due to confusion in the literature, a meta-analysis was carried out to evaluate whether there is a real effect of smoking in these diseases. Research was conducted in PubMed and Google Scholar and a combined OR was calculated, based on the fixed effects model, of the studies which met the established inclusion criteria. Our results confirm that smoking is a protective factor for ulcerative colitis with statistically significant combined ORs, similar to those of other previously performed meta-analyses. Nevertheless, the association of smoking as a risk factor for Crohn’s disease is not so clear, due to the fact that the combined ORs obtained are not significant or are close to non-significant and are smaller than in other meta-analyses, although we did detect that it should be analyzed in forthcoming studies.

Bibliographic References

  • Abraham N, Selby W, Lazarus R, Solomon M. Is smoking an indirect risk factor for the development of ulcerative colitis? An age- and sex-matched case-control study. J Gastroenterol Hepatol. 2003; 18(2):139-146.
  • Berkowitz L, Schultz BM, Salazar GA, Pardo-Roa C, Sebastián VP, Álvarez-Lobos MM et al. Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis. Front Immunol. 2018; 9(74).
  • Boyko EJ, Koepsell TD, Perera DR, Inui TS. Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med. 1987; 316(12):707-710.
  • Calkins BM. A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci. 1989; 34(12):1841-1854.
  • Fich A, Eliakim R, Sperber AD, Carel RS, Rachmilewitz D. The association between smoking and inflammatory bowel disease among Israeli Jewish patients. Inflamm Bowel Dis. 1997; 3(1):6-9.
  • Fraga XF, Vergara M, Medina C, Casellas F, Bermejo B, Malagelada JR. Effects of smoking on the presentation and clinical course of inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1997; 9(7):683-687.
  • Gompertz M, Sedano R. Manifestaciones clínicas y endoscópicas en enfermedad inflamatoria intestinal. Rev Med Clín Las Condes. 2019; 30(4):273-282.
  • Hwang SW, Seo H, Kim G-U, Song EM, Seo M, Park SH et al. Underestimation of smoking rates in an East Asian population with Crohn’s disease. Gut Liver. 2017; 11(1):73-78.
  • Lindberg E, Tysk C, Andersson K, Jarnerot G. Smoking and inflammatory bowel disease. A case control study. Gut. 1988; 29(3):352-357.
  • Logan RF, Edmond M, Somerville KW, Langman MJ. Smoking and ulcerative colitis. Br Med J (Clin Res Ed). 1984; 288(6419):751-753.
  • Mahid SS, Minor KS, Soto RE, Hornung CA, Galandiuk S. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clin Proc. 2006; 81(11):1462-1471.
  • Nishikawa A, Tanaka K, Miyake Y, Nagata C, Furukawa S, Andoh A et al. Active and passive smoking and risk of ulcerative colitis: A case-control study in Japan. J Gastroenterol Hepatol. 2022; 37(4):653-659.
  • Park SC, Jeen YT. Role of smoking as a risk factor in east Asian patients with Crohn’s disease. Gut Liver. 2017; 11(1):7-8.
  • Persson PG, Ahlbom A, Hellers G. Inflammatory bowel disease and tobacco smoke-a case-control study. Gut. 1990; 31(12):1377-1381.
  • Reif S, Klein I, Arber N, Gilat T. Lack of association between smoking and inflammatory bowel disease in Jewish patients in Israel. Gastroenterology. 1995; 108(6):1683-1687.
  • Reif S, Lavy A, Keter D, Fich A, Eliakim R, Halak A et al. Lack of association between smoking and Crohn’s disease but the usual association with ulcerative colitis in Jewish patients in Israel: a multicenter study. Am J Gastroenterology. 2000; 95(2):474-478.
  • Silva F, Gatica T, Pavez C. Etiología y fisiopatología de la enfermedad inflamatoria intestinal. Rev Médica Clín Las Condes. 2019; 30(4):262-272.
  • Silverstein MD, Lashner BA, Hanauer SB. Cigarette smoking and ulcerative colitis: a case-control study. Mayo Clin Proc. 1994; 69(5):425-429.
  • Thomas GA, Rhodes J, Green JT, Richardson, C. Role of smoking in inflammatory bowel disease: implications for therapy. Postgrad Med J. 2000; 76(895):273-279.
  • Tuvlin JA, Raza SS, Bracamonte S, Julian C, Hanauer SB, Nicolae DL et al. Smoking and inflammatory bowel disease: Trends in familial and sporadic cohorts. Inflamm Bowel Dis. 2007; 13(5):573-579.
  • Wang P, Hu J, Ghadermarzi S, Raza A, O’Connell D, Xiao A et al. Smoking and Inflammatory Bowel Disease: A Comparison of China, India, and the USA. Dig Dis Sci. 2018; 63(10):2703-2713.
Data source: Dialnet