Efecto del hipotiroidismo congénito sobre el desarrollo postnatal de la mitocondria de hígado de rata

Abstract

  The effects of congenital hypothyroidism on postnatal changes of rhodamine 123- stained mitochondrial populations, respiratory function and osmotic activity of rat liver mitochondria have been studied. Hypothyroidism prevented the postnatal increase in the percentage of mitochondrial low fluorescence population (LFP, mature form) that occurs immediately after birth. This effect coincides with the prevention of postnatal onset of respiratory function and osmotic activity of liver mitochondria from hypothyroid newboms. The administration of thyroid hormones to hypothyroid newboms at birth reversed all these c::ffects, reaching levels of maturation similar to those of euthyroid newboms. The effect of thyroid hormones on the percentage of mitochondrial populations and on the functional (RCR) and structural (osmotic activity) maturation were prevented by cycloheximide supplement. Our results suggest that thyroid hormones regulate postnatal development of liver mitochondria through the synthesis of some(s) protein(s) involved in the FO,FI-ATPase assembly.