La albúmina se comporta como un potente activador de la piruvato deshidrogenasa en neuronas y astrocitos de rata en cultivo primario

1. TABERNERO, A.
2. MEDINA, A.
3. SÁNCHEZ-ABARCA, L.
4. MEDINA, J.M.

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More publications in: Ars pharmaceutica

Abstract

Albumin is uptaken by newborn brain from blood during the perinatal period (1). Previous works showed that the presence of albumin activated newborn brain metabolism (2) in both neurons and astrocytes (3). In this work, the metabolic pathways implicated in this effect has been studied. The fate of glucose was studied using 14C-Iabeled glucose in different carbons in the presence or in the absence of albumin as it has been previously reported (4) . Rere we report that albumin highly activated pyruvate dehydrogenase-catalyzed reaction. Since the tricarboxylic acid cycle was not activated to the same extent, the efflux of carbons from the pyruvate dehydrogenase-catalyzed reaction was strongly increased. Albumin activated the pentose phosphate shunt and the trycarboxylic acid cycle in astrocytes but not in neurons. Our results showed that albumin activated astrocytes metabolism by two mechanism, and one of them was calcium-dependent.

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