Evolución de virus respiratorios sincitiales humanos que tienen una duplicación de 60 nucleótidos en el gen de la proteína G

  1. Trento, Maria Alfonsina
Dirigida por:
  1. José Antonio Melero Fondevila Director/a

Universidad de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 27 de julio de 2009

Tribunal:
  1. Esteban Domingo Solans Presidente/a
  2. José María Almendral del Río Secretario/a
  3. Enrique Villar Ledesma Vocal
  4. Amelia Nieto Martín Vocal
  5. Juan Ortín Montón Vocal

Tipo: Tesis

Teseo: 305274 DIALNET lock_openBiblos-e Archivo editor

Resumen

Human respiratory syncytial virus (HRSV) belongs to the family Paramyxoviridae. It is the main cause of severe lower respiratory tract infections in very young children and is also a common cause of respiratory infections in elderly and immunocompromised individuals. Currently, no effective vaccine exists against this virus. Studies of HRSV evolution by sequence analysis have focused mainly on the G protein gene for two reasons: i) the G protein displays the highest antigenic and genetic variability among HRSV gene products and ii) the G protein is one of the targets for neutralizing and protective antibodies.