Producción de metabolitos secundarios en Streptomyces: regulación, estudio y mejora de cepas productoras

  1. Ramón Santamaría Sánchez
  2. Margarita María Díaz Martínez
  3. Eva López Delgado 1
  4. Ramiro Morán Cacho 1
  5. María Lorenzo Sánchez 1
  6. Javier García Martín
  7. Carolina Riascos Cuero
  1. 1 Instituto de Biología Funcional y Genómica
    info

    Instituto de Biología Funcional y Genómica

    Salamanca, España

Revista:
SEM@foro

ISSN: 2254-4399

Año de publicación: 2023

Número: 76

Páginas: 56-58

Tipo: Artículo

Otras publicaciones en: SEM@foro

Referencias bibliográficas

  • Antoraz, S. (2018) Mejora genética de cepas de Streptomyces coelicolor para la producción de metabolitos secundarios mediante el estudio de su regulación por sistemas de dos componentes. In: University of Salamanca. Spain, p. Doctoral Thesis. https://digital.csic.es/ handle/10261/183634
  • Antoraz, S., Rico, S., Rodríguez, H., Sevillano, L., Alzate, J.F., Santamaría, R.I. et al. (2017) The Orphan Response Regulator Aor1 Is a New Relevant Piece in the Complex Puzzle of Streptomyces coelicolor Antibiotic Regulatory Network. Front Microbiol 8: 2444. doi: https://doi. org/10.3389/fmicb.2017.02444
  • Becerril, A., Álvarez, S., Braña, A.F., Rico, S., Díaz, M., Santamaría, R.I. et al. (2018) Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches. PLoS One 13: e0198145. h t t p s : / / d o i . o r g / 1 0 . 1 3 7 1 / j o u r n a l . pone.0198145
  • Koteva, K., Hong, H.J., Wang, X.D., Nazi, I., Hughes, D., Naldrett, M.J. et al. (2010) A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. Nat Chem Biol 6: 327-329. https:// doi.org/10.1038/nchembio.350
  • Li, L., Jiang, W., and Lu, Y. (2017) A Novel Two-Component System, GluR-GluK, Involved in Glutamate Sensing and Uptake in Streptomyces coelicolor. J Bacteriol 199. https://doi.org/10.1128/JB.00097-17
  • Riascos, C., Martínez-Carrasco, A., Díaz, M., and Santamaría, R.I. (2023) Role of fourteen XRE-DUF397 pairs from Streptomyces coelicolor as regulators of antibiotic production and differentiation. New players in a complex regulatory network. Front Microbiol 14: 1217350. https://doi.org/10.3389/fmicb.2023.1217350
  • Rico, S., Santamaría, R.I., Yepes, A., Rodríguez, H., Laing, E., Bucca, G. et al. (2014a) Deciphering the Regulon of Streptomyces coelicolor AbrC3, a Positive Response Regulator of Antibiotic Production. Applied and Environmental Microbiology 80: 2417-2428. doi: https:// doi.org/10.1128/AEM.03378-13
  • Rico, S., Yepes, A., Rodríguez, H., Santamaría, J., Antoraz, S., Krause, E.M. et al. (2014b) Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production. PloS one 9: e109844. https:// doi.org/10.1371/journal.pone.0109844
  • Rodríguez, H., Rico, S., Díaz, M., and Santamaría, R.I. (2013) Two-component systems in Streptomyces: key regulators of antibiotic complex pathways. Microbial cell factories 12: 127. doi: https://doi. org/10.1186/1475-2859-12-127
  • Rodríguez, H., Rico, S., Yepes, A., FrancoEchevarría, E., Antoraz, S., Santamaría, R.I. et al. (2015) The two kinases, AbrC1 and AbrC2, of the atypical two-component system AbrC are needed to regulate antibiotic production and differentiation in Streptomyces coelicolor. Frontiers in microbiology 6: 450. doi: https://doi. org/10.3389/fmicb.2015.00450
  • Sánchez de la Nieta, R. (2022) Sistemas de dos componentes de Streptomyces coelicolor, pilares en la producción de antibióticos. In: University of Salamanca. Spain, Doctoral Thesis. https://digital.csic. es/handle/10261/306195
  • Sánchez de la Nieta, R., Santamaría, R.I., and Díaz, M. (2022) Two-Component Systems of Streptomyces coelicolor: An Intricate Network to Be Unraveled. International Journal of Molecular Sciences 23: 15085. https://doi.org/10.3390/ ijms232315085
  • Sánchez de la Nieta, R., Antoraz, S., Alzate, J.F., Santamaría, R.I., and Díaz, M. (2020) Antibiotic Production and Antibiotic Resistance: The Two Sides of AbrB1/B2, a Two-Component System of Streptomyces coelicolor. Front Microbiol 11: 587750. https://doi.org/10.3389/ fmicb.2020.587750
  • Santamaría, R.I., Sevillano, L., Martín, J., Genilloud, O., González, I., and Díaz, M. (2018) The XRE-DUF397 Protein Pair, Scr1 and Scr2, Acts as a Strong Positive Regulator of Antibiotic Production in Streptomyces. Frontiers in Microbiology 9. https://doi.org/10.3389/fmicb.2018.02791