Javier
Robles Valero
Profesor Asociado
Luis Francisco
Lorenzo Martín
Publications by the researcher in collaboration with Luis Francisco Lorenzo Martín (10)
2022
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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Cell Reports, Vol. 38, Núm. 11
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Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model
Molecular Oncology, Vol. 16, Núm. 19, pp. 3533-3553
2021
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Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis
EMBO Journal, Vol. 40, Núm. 22
2020
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Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
Frontiers in Cell and Developmental Biology, Vol. 8
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Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera
Small GTPases, Vol. 11, Núm. 4, pp. 233-239
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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Nature Communications, Vol. 11, Núm. 1
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Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor
Oncogene, Vol. 39, Núm. 28, pp. 5098-5111
2019
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Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms
Oncogene, Vol. 38, Núm. 2, pp. 209-227
2018
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An unexpected tumor suppressor role for VAV1a
Molecular and Cellular Oncology, Vol. 5, Núm. 3
2017
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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
Cancer Cell, Vol. 32, Núm. 5, pp. 608-623.e9