Publicaciones (20) Publicaciones de Javier Robles Valero

2022

  1. A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

    Cell Reports, Vol. 38, Núm. 11

  2. Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model

    Molecular Oncology, Vol. 16, Núm. 19, pp. 3533-3553

2021

  1. Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis

    EMBO Journal, Vol. 40, Núm. 22

  2. Distinct roles of vav family members in adaptive and innate immune models of arthritis

    Biomedicines, Vol. 9, Núm. 6

  3. Vav proteins as double agents in cancer: Oncogenes with tumor suppressor roles

    Biology, Vol. 10, Núm. 9

2020

  1. Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

    Frontiers in Cell and Developmental Biology, Vol. 8

  2. Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera

    Small GTPases, Vol. 11, Núm. 4, pp. 233-239

  3. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

    Nature Communications, Vol. 11, Núm. 1

  4. Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor

    Oncogene, Vol. 39, Núm. 28, pp. 5098-5111

2019

  1. Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

    Oncogene, Vol. 38, Núm. 2, pp. 209-227

2018

  1. An unexpected tumor suppressor role for VAV1a

    Molecular and Cellular Oncology, Vol. 5, Núm. 3

2017

  1. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia

    Cancer Cell, Vol. 32, Núm. 5, pp. 608-623.e9

  2. Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 4, pp. 764-769

2016

  1. Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge

    European Journal of Immunology, Vol. 46, Núm. 10, pp. 2376-2387

2015

  1. Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions

    Molecular and Cellular Biology, Vol. 35, Núm. 20, pp. 3528-3546

  2. The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathwayspecific signaling defects

    Molecular Biology of the Cell, Vol. 26, Núm. 16, pp. 2895-2912

2014

  1. Miro-1 links mitochondria and microtubule dynein motors to control lymphocyte migration and polarity

    Molecular and Cellular Biology, Vol. 34, Núm. 8, pp. 1412-1426

2011

  1. Endosomal clathrin drives actin accumulation at the immunological synapse

    Journal of Cell Science, Vol. 124, Núm. 5, pp. 820-830

2010

  1. Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450

    Blood, Vol. 115, Núm. 21, pp. 4174-4184

2008

  1. MTOC translocation modulates IS formation and controls sustained T cell signaling

    Journal of Cell Biology, Vol. 182, Núm. 5, pp. 951-962