Javier
Robles Valero
Profesor Asociado
Publications (20) Javier Robles Valero publications
2022
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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Cell Reports, Vol. 38, Núm. 11
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Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model
Molecular Oncology, Vol. 16, Núm. 19, pp. 3533-3553
2021
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Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis
EMBO Journal, Vol. 40, Núm. 22
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Distinct roles of vav family members in adaptive and innate immune models of arthritis
Biomedicines, Vol. 9, Núm. 6
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Vav proteins as double agents in cancer: Oncogenes with tumor suppressor roles
Biology, Vol. 10, Núm. 9
2020
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Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
Frontiers in Cell and Developmental Biology, Vol. 8
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Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera
Small GTPases, Vol. 11, Núm. 4, pp. 233-239
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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Nature Communications, Vol. 11, Núm. 1
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Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor
Oncogene, Vol. 39, Núm. 28, pp. 5098-5111
2019
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Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms
Oncogene, Vol. 38, Núm. 2, pp. 209-227
2018
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An unexpected tumor suppressor role for VAV1a
Molecular and Cellular Oncology, Vol. 5, Núm. 3
2017
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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
Cancer Cell, Vol. 32, Núm. 5, pp. 608-623.e9
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Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 4, pp. 764-769
2016
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Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge
European Journal of Immunology, Vol. 46, Núm. 10, pp. 2376-2387
2015
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Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions
Molecular and Cellular Biology, Vol. 35, Núm. 20, pp. 3528-3546
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The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathwayspecific signaling defects
Molecular Biology of the Cell, Vol. 26, Núm. 16, pp. 2895-2912
2014
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Miro-1 links mitochondria and microtubule dynein motors to control lymphocyte migration and polarity
Molecular and Cellular Biology, Vol. 34, Núm. 8, pp. 1412-1426
2011
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Endosomal clathrin drives actin accumulation at the immunological synapse
Journal of Cell Science, Vol. 124, Núm. 5, pp. 820-830
2010
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Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450
Blood, Vol. 115, Núm. 21, pp. 4174-4184
2008
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MTOC translocation modulates IS formation and controls sustained T cell signaling
Journal of Cell Biology, Vol. 182, Núm. 5, pp. 951-962