Publicaciones (154) Publicaciones de PEDRO ALFONSO LAZO-ZBIKOWSKI TARACENA

2024

  1. Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin

    Chemico-Biological Interactions, Vol. 391

  2. Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy

    Journal of Molecular Medicine

2023

  1. The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase

    Epigenetics and Chromatin, Vol. 16, Núm. 1

  2. VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1

    International Journal of Molecular Sciences, Vol. 24, Núm. 5

  3. VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases

    Neurobiology of Disease, Vol. 183

2022

  1. Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?

    Cancers, Vol. 14, Núm. 16

  2. The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage

    Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, Vol. 1865, Núm. 8

2021

  1. Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia

    Neurology: Genetics, Vol. 7, Núm. 5

  2. Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy

    Frontiers in Cell and Developmental Biology, Vol. 9

  3. Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome

    Human Genomics, Vol. 15, Núm. 1

  4. The human VRK1 chromatin kinase in cancer biology

    Cancer Letters

  5. VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells

    Frontiers in Cell and Developmental Biology, Vol. 9

2020

  1. Novel dominant kcnq2 exon 7 partial in-frame duplication in a complex epileptic and neurodevelopmental delay syndrome

    International Journal of Molecular Sciences, Vol. 21, Núm. 12, pp. 1-11

  2. VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy

    Annals of Clinical and Translational Neurology, Vol. 7, Núm. 5, pp. 808-818

  3. Vrk1 phosphorylates tip60/kat5 and is required for h4k16 acetylation in response to dna damage

    Cancers, Vol. 12, Núm. 10, pp. 1-24

2019

  1. Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

    Journal of Experimental and Clinical Cancer Research, Vol. 38, Núm. 1

  2. VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

    Scientific Reports, Vol. 9, Núm. 1

2018

  1. Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

    Cellular and Molecular Life Sciences, Vol. 75, Núm. 13, pp. 2375-2388

  2. VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis

    Cellular and Molecular Life Sciences, Vol. 75, Núm. 14, pp. 2591-2611

2017

  1. Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?

    American Journal of Pathology, Vol. 187, Núm. 3, pp. 494-497