Publicaciones (33) Publicaciones de Mercedes Dosil Castro

2024

  1. VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

    Scientific Reports, Vol. 14, Núm. 1

2023

  1. Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors

    Oncogene, Vol. 42, Núm. 5, pp. 389-405

2022

  1. A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

    Cell Reports, Vol. 38, Núm. 11

  2. Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model

    Molecular Oncology, Vol. 16, Núm. 19, pp. 3533-3553

  3. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

    Oncogene, Vol. 41, Núm. 24, pp. 3341-3354

2021

  1. Efficient fractionation and analysis of ribosome assembly intermediates in human cells

    RNA Biology, Vol. 18, Núm. S1, pp. 182-197

  2. New functions of vav family proteins in cardiovascular biology, skeletal muscle, and the nervous system

    Biology, Vol. 10, Núm. 9

2020

  1. Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

    Nature Communications, Vol. 11, Núm. 1

  2. Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor

    Oncogene, Vol. 39, Núm. 28, pp. 5098-5111

2019

  1. Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae

    RNA, Vol. 25, Núm. 11, pp. 1561-1575

  2. Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

    Oncogene, Vol. 38, Núm. 2, pp. 209-227

2018

  1. Ribosome biogenesis and cancer: basic and translational challenges

    Current Opinion in Genetics and Development, Vol. 48, pp. 22-29

2017

  1. Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast

    RNA, Vol. 23, Núm. 9, pp. 1432-1443

2014

  1. Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

    Nature Communications, Vol. 5

  2. Rrp12 and the Exportin Crm1 Participate in Late Assembly Events in the Nucleolus during 40S Ribosomal Subunit Biogenesis

    PLoS Genetics, Vol. 10, Núm. 12

2011

  1. Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes

    Nucleic Acids Research, Vol. 39, Núm. 18, pp. 8105-8121

  2. Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response

    Molecular and Cellular Biology, Vol. 31, Núm. 12, pp. 2422-2438

2010

  1. Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast

    Methods in Enzymology (Academic Press Inc.), pp. 329-348

2007

  1. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism

    Molecular and Cellular Biology, Vol. 27, Núm. 15, pp. 5414-5429

2005

  1. Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav

    Blood, Vol. 105, Núm. 8, pp. 3026-3034