Publicaciones (75) Publicaciones de Rafael Peláez Lamamie de Claira Arroyo

2024

  1. Experimental structure based drug design (SBDD) applications for anti-leishmanial drugs: A paradigm shift?

    Medicinal Research Reviews, Vol. 44, Núm. 3, pp. 1055-1120

2023

  1. Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition

    International Journal of Molecular Sciences, Vol. 24, Núm. 24

  2. GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution

    Structure, Vol. 31, Núm. 12, pp. 1526-1534.e4

  3. Novel Tetrazole Derivatives Targeting Tubulin Endowed with Antiproliferative Activity against Glioblastoma Cells

    International Journal of Molecular Sciences, Vol. 24, Núm. 13

  4. Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy

    Bioorganic Chemistry, Vol. 131

  5. Nuevos antitumorales y antiparasitarios de naturaleza híbrida para la formación de nanopartículas

    IX Jornadas de investigadoras de Castilla y León

  6. Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents

    Pharmaceutics, Vol. 15, Núm. 6

2022

  1. Modelo in vitro para evaluar la actividad de compuestos antiparasitarios frente a Trichinella spiralis

    XII Congreso de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI)

  2. Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells

    International Journal of Molecular Sciences, Vol. 23, Núm. 21

2021

  1. Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

    European Journal of Medicinal Chemistry, Vol. 223

  2. Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors

    Computational and Structural Biotechnology Journal, Vol. 19, pp. 4360-4372

  3. Methoxy and bromo scans on N-(5-methoxyphenyl) methoxybenzenesulphonamides reveal potent cytotoxic compounds, especially against the human breast adenocarcinoma MCF7 cell line

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 1029-1047

  4. Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

    European Journal of Medicinal Chemistry, Vol. 209

  5. Microtubule destabilizing sulfonamides as an alternative to taxane-based chemotherapy

    International Journal of Molecular Sciences, Vol. 22, Núm. 4, pp. 1-21

  6. New diarylsulfonamide inhibitors of Leishmania infantum amastigotes

    International Journal for Parasitology: Drugs and Drug Resistance, Vol. 16, pp. 45-64

  7. New indolesulfonamide derivatives targeting the colchicine site of tubulin: synthesis, anti-tumour activity, structure–activity relationships, and molecular modelling

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 36, Núm. 1, pp. 2025-2044

2020

  1. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

    Bioorganic Chemistry, Vol. 98

2019

  1. Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

    Medicinal Research Reviews, Vol. 39, Núm. 3, pp. 775-830

  2. Design, Synthesis and Biological Evaluation of Benzodiazepines Analogues as Anti-Tubuling Agents

    FarmaJournal

  3. Diseño, síntesis y evaluación de amidas y sulfonamidas con actividad tipo colchicina contra Strongyloides venezuelensis

    XI Congreso de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI)