Publications (21) Consuelo Gajate Fraile publications

2021

  1. Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents

    European Journal of Medicinal Chemistry, Vol. 209

  2. Neutrophils drive endoplasmic reticulum stress-mediated apoptosis in cancer cells through arginase-1 release

    Scientific Reports, Vol. 11, Núm. 1

2020

  1. Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring

    Bioorganic Chemistry, Vol. 98

2018

  1. Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

    European Journal of Medicinal Chemistry, Vol. 158, pp. 167-183

2017

  1. Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine

    PLoS Neglected Tropical Diseases, Vol. 11, Núm. 8

2016

  1. Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

    Pharmacology and Therapeutics, Vol. 165, pp. 114-131

  2. The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death

    Acta Tropica, Vol. 162, pp. 180-187

2015

  1. Eficacia de alquil-fosfolípidos frente a Strongyloides venezuelensis

    XIX Congreso de la Sociedad Española de Parasitología (SOCEPA)

  2. Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine

    Oncotarget, Vol. 6, Núm. 16, pp. 14596-14613

  3. Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

    Journal of Leukocyte Biology, Vol. 98, Núm. 5, pp. 739-759

  4. Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling

    Apoptosis, Vol. 20, Núm. 5, pp. 584-606

  5. Lipid rafts as major platforms for signaling regulation in cancer

    Advances in Biological Regulation, Vol. 57, pp. 130-146

  6. Triggers and signaling cross-talk controlling cell death commitment

    Cell Cycle

2014

  1. Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine

    Anti-Cancer Agents in Medicinal Chemistry, Vol. 14, Núm. 4, pp. 509-527

2013

  1. Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast

    Journal of Biological Chemistry, Vol. 288, Núm. 12, pp. 8405-8418

2012

  1. Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxide

    Parasite Immunology, Vol. 34, Núm. 12, pp. 570-580

2009

  1. Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis

    Journal of Pharmacology and Experimental Therapeutics, Vol. 329, Núm. 2, pp. 439-449

2008

  1. Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo

    Cancer Research, Vol. 68, Núm. 13, pp. 5216-5225

2005

  1. Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety

    Journal of Medicinal Chemistry, Vol. 48, Núm. 2, pp. 556-568

2004

  1. Synthesis and Biological Evaluation of New Selective Cytotoxic Cyclolignans Derived from Podophyllotoxin

    Journal of Medicinal Chemistry, Vol. 47, Núm. 5, pp. 1214-1222