BIOCIENCIAS: Bª Y CLÍNICA DEL CÁNCER Y MEDIC. TRASLACIONAL
Escuela de doctorado
Luis Francisco
Lorenzo Martín
Publicaciones en las que colabora con Luis Francisco Lorenzo Martín (27)
2024
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VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma
Scientific Reports, Vol. 14, Núm. 1
2023
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Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors
Oncogene, Vol. 42, Núm. 5, pp. 389-405
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The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome
Frontiers in Cell and Developmental Biology, Vol. 11
2022
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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
Cell Reports, Vol. 38, Núm. 11
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Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model
Molecular Oncology, Vol. 16, Núm. 19, pp. 3533-3553
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CiberAMP: An R Package to Identify Differential mRNA Expression Linked to Somatic Copy Number Variations in Cancer Datasets
Biology, Vol. 11, Núm. 10
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The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
Oncogene, Vol. 41, Núm. 24, pp. 3341-3354
2021
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Aryl hydrocarbon receptor controls skin homeostasis, regeneration, and hair follicle cycling by adjusting epidermal stem cell function
Stem Cells, Vol. 39, Núm. 12, pp. 1733-1750
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Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis
EMBO Journal, Vol. 40, Núm. 22
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New functions of vav family proteins in cardiovascular biology, skeletal muscle, and the nervous system
Biology, Vol. 10, Núm. 9
2020
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Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity
Frontiers in Cell and Developmental Biology, Vol. 8
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Drug vulnerabilities and disease prognosis linked to the stem cell-like gene expression program triggered by the RHO GTPase activator VAV2 in hyperplastic keratinocytes and head and neck cancer
Cancers, Vol. 12, Núm. 9, pp. 1-14
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Herc ubiquitin ligases in cancer
Cancers, Vol. 12, Núm. 6, pp. 1-13
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In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells
Cells, Vol. 9, Núm. 1
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Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
Cells, Vol. 9, Núm. 3
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Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera
Small GTPases, Vol. 11, Núm. 4, pp. 233-239
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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
Nature Communications, Vol. 11, Núm. 1
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Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
Nature Communications, Vol. 11, Núm. 1
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Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor
Oncogene, Vol. 39, Núm. 28, pp. 5098-5111
2019
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Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output
Cells, Vol. 8, Núm. 12