Búsqueda de bacterias productoras de antibióticos a partir del culturoma rizosférico
- Fernández-Villacorta, Noelia 1
- Mateos, Pedro F. 1
- Saati-Santamaría, Zaki 1
-
1
Universidad de Salamanca
info
ISSN: 2445-1355
Any de publicació: 2020
Volum: 5
Número: 2
Pàgines: 43-50
Tipus: Article
Altres publicacions en: Farmajournal
Resum
The inappropriate use of antibiotics has increased the number illnesses and deaths because of multidrug resistant microbial caused infections. The objective of this study was to isolate rhizospheric bacteria and evaluate their potential to produce antimicrobial compounds. 418 bacterial colonies were isolated and assayed against bacteria and fungi in order to analyze their antimicrobial potential, finding 114 antimicrobial producing strains. Two of these strains with best antimicrobial spectrum of action were selected for further analyses, and were identified as Bacillus albus and Streptomycs cirratus. Their genomes were sequenced and secondary metabolism pathways were analyzed, finding genetic machinery potentially implicated in the production of new bioactive compounds.
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