MANUEL
MEDARDE AGUSTÍN
Investigador en el periodo 1984-2021
Publicaciones en las que colabora con MANUEL MEDARDE AGUSTÍN (72)
2019
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The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors
Molecules (Basel, Switzerland), Vol. 24, Núm. 23
2016
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Pyridine based antitumour compounds acting at the colchicine site
Current Medicinal Chemistry, Vol. 23, Núm. 11, pp. 1100-1130
2015
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Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para -nitrogen substituted isocombretastatins
European Journal of Medicinal Chemistry, Vol. 100, pp. 210-222
2011
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Synthesis of novel polynitrogenated drugs based on phenstatins. Tubulin polymerization evaluation
4TH EUROPEAN CONFERENCE ON CHEMISTRY FOR LIFE SCIENCES
2010
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Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
European Journal of Medicinal Chemistry, Vol. 45, Núm. 2, pp. 588-597
2008
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Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 11, pp. 5952-5961
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Imino-Diels-Alder reactions of 1-aryl-3-(trialkylsiloxy)-1,3-butadienes in solution and the solid phase
European Journal of Organic Chemistry, pp. 4004-4014
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Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 19, pp. 8999-9008
2007
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Conformationally restricted macrocyclic analogues of combretastatins
Bioorganic and Medicinal Chemistry Letters, Vol. 17, Núm. 22, pp. 6316-6320
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New nitrogenated siloxy butadienes from 1,3-dichloroacetone
Tetrahedron Letters, Vol. 48, Núm. 6, pp. 907-910
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Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins
Bioorganic and Medicinal Chemistry Letters, Vol. 17, Núm. 12, pp. 3417-3420
2006
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Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines
Molecules, Vol. 11, Núm. 11, pp. 929-939
2005
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Diels-Alder reactivity of 4-aryl-1-phthalimido-2-siloxy-1,3-butadienes
Tetrahedron, Vol. 61, Núm. 28, pp. 6871-6878
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Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety
Journal of Medicinal Chemistry, Vol. 48, Núm. 2, pp. 556-568
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New naphthylcombretastatins. Modifications on the ethylene bridge
Bioorganic and Medicinal Chemistry, Vol. 13, Núm. 6, pp. 2097-2107
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New synthesis of arcyriaflavin-A via silyl enol ether-mediated and Fischer indolisations
Tetrahedron Letters, Vol. 46, Núm. 29, pp. 4839-4841
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Stilbenophane analogues of deoxycombretastatin A-4
Journal of Organic Chemistry, Vol. 70, Núm. 16, pp. 6544-6547
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Synthesis of a conformationally restricted polyoxygenated crownophane
Tetrahedron Letters, Vol. 46, Núm. 41, pp. 7055-7057
2004
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1-Phthalimido-4-(3-indolyl)-2-siloxy-1,3-butadienes: Synthesis and Diels-Alder reactivity
Tetrahedron Letters, Vol. 45, Núm. 8, pp. 1631-1634
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A new family of quinoline and quinoxaline analogues of combretastatins
Bioorganic and Medicinal Chemistry Letters, Vol. 14, Núm. 14, pp. 3771-3774