BIOCIENCIAS: Bª Y CLÍNICA DEL CÁNCER Y MEDIC. TRASLACIONAL
Escuela de doctorado
Raquel
Álvarez Lozano
Profesora Titular de Universidad
Publicaciones en las que colabora con Raquel Álvarez Lozano (22)
2023
2021
-
Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents
European Journal of Medicinal Chemistry, Vol. 209
-
Microtubule destabilizing sulfonamides as an alternative to taxane-based chemotherapy
International Journal of Molecular Sciences, Vol. 22, Núm. 4, pp. 1-21
-
New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
International Journal for Parasitology: Drugs and Drug Resistance, Vol. 16, pp. 45-64
2020
2019
-
Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target
Medicinal Research Reviews, Vol. 39, Núm. 3, pp. 775-830
-
Design, Synthesis and Biological Evaluation of Benzodiazepines Analogues as Anti-Tubuling Agents
FarmaJournal
-
Diseño, síntesis y evaluación de amidas y sulfonamidas con actividad tipo colchicina contra Strongyloides venezuelensis
XI Congreso de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI)
-
The Masked Polar Group Incorporation (MPGI) Strategy in Drug Design: Effects of Nitrogen Substitutions on Combretastatin and Isocombretastatin Tubulin Inhibitors
Molecules (Basel, Switzerland), Vol. 24, Núm. 23
2018
-
Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells
European Journal of Medicinal Chemistry, Vol. 158, pp. 167-183
2016
-
Pyridine based antitumour compounds acting at the colchicine site
Current Medicinal Chemistry, Vol. 23, Núm. 11, pp. 1100-1130
2015
-
Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para -nitrogen substituted isocombretastatins
European Journal of Medicinal Chemistry, Vol. 100, pp. 210-222
2014
-
New ligands of the tubulin colchicine site based on X-ray structures
Current Topics in Medicinal Chemistry, Vol. 14, Núm. 20, pp. 2231-2252
-
P, p -dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin Inhibition
Journal of Organic Chemistry, Vol. 79, Núm. 15, pp. 6840-6857
2013
-
Endowing indole-based tubulin inhibitors with an anchor for derivatization: Highly potent 3-substituted indolephenstatins and indoleisocombretastatins
Journal of Medicinal Chemistry, Vol. 56, Núm. 7, pp. 2813-2827
2011
-
New para-para stilbenophanes: Synthesis by mcmurry coupling, conformational analysis and inhibition of tubulin polymerisation
Chemistry - A European Journal, Vol. 17, Núm. 12, pp. 3406-3419
2010
-
Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
European Journal of Medicinal Chemistry, Vol. 45, Núm. 2, pp. 588-597
2009
-
Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 17, pp. 6422-6431
2008
-
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 11, pp. 5952-5961
-
Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation
Bioorganic and Medicinal Chemistry, Vol. 16, Núm. 19, pp. 8999-9008