Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles

  1. Symonds, Catherine Evangeline
unter der Leitung von:
  1. Mariano Barbacid Montalbán Doktorvater/Doktormutter
  2. David Santamaría Velilla Co-Doktorvater

Universität der Verteidigung: Universidad Autónoma de Madrid

Fecha de defensa: 16 von Juli von 2015

Gericht:
  1. Manuel Serrano Marugán Präsident/in
  2. Marcos Malumbres Sekretär/in
  3. Ángel Rodríguez Nebreda Vocal
  4. Javier León Serrano Vocal
  5. Sergio Moreno Pérez Vocal

Art: Dissertation

Teseo: 394890 DIALNET lock_openBiblos-e Archivo editor

Zusammenfassung

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).