Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles
- Symonds, Catherine Evangeline
- Mariano Barbacid Montalbán Director
- David Santamaría Velilla Co-director
Universidade de defensa: Universidad Autónoma de Madrid
Fecha de defensa: 16 de xullo de 2015
- Manuel Serrano Marugán Presidente/a
- Marcos Malumbres Secretario/a
- Ángel Rodríguez Nebreda Vogal
- Javier León Serrano Vogal
- Sergio Moreno Pérez Vogal
Tipo: Tese
Resumo
Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).