Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles

  1. Symonds, Catherine Evangeline
Supervised by:
  1. Mariano Barbacid Montalbán Director
  2. David Santamaría Velilla Co-director

Defence university: Universidad Autónoma de Madrid

Fecha de defensa: 16 July 2015

Committee:
  1. Manuel Serrano Marugán Chair
  2. Marcos Malumbres Secretary
  3. Ángel Rodríguez Nebreda Committee member
  4. Javier León Serrano Committee member
  5. Sergio Moreno Pérez Committee member

Type: Thesis

Teseo: 394890 DIALNET lock_openBiblos-e Archivo editor

Abstract

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).