Genetic characterization of cdk1 in mouse development and homeostasis; A novel dichotomy between stem and committed mitotic cell cycles

  1. Symonds, Catherine Evangeline
Dirigida por:
  1. Mariano Barbacid Montalbán Director/a
  2. David Santamaría Velilla Codirector

Universidad de defensa: Universidad Autónoma de Madrid

Fecha de defensa: 16 de julio de 2015

Tribunal:
  1. Manuel Serrano Marugán Presidente/a
  2. Marcos Malumbres Secretario/a
  3. Ángel Rodríguez Nebreda Vocal
  4. Javier León Serrano Vocal
  5. Sergio Moreno Pérez Vocal

Tipo: Tesis

Teseo: 394890 DIALNET lock_openBiblos-e Archivo editor

Resumen

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle progression and transcription control. For this reason, CDKs have long been considered attractive therapeutic targets to treat hyperproliferative diseases such as cancer. Yet, the number of Cdks has significantly increased during evolution. My laboratory han been implicated in the genetic characterization of the CDK family with the aim of identifying essential and redundant functions among the diferente members. (extracto del informe del doctor D. Mariano Barbacid Montalbán).